Arun Dharmarajan
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Explore the profile of Arun Dharmarajan including associated specialties, affiliations and a list of published articles.
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71
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1194
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Recent Articles
1.
Soumya B, Gamit N, Patil M, Shreenidhi V, Dharmarajan A, Warrier S
Exp Cell Res
. 2025 Feb;
446(1):114449.
PMID: 39961464
Advancement of therapeutics for neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) has been predominantly hampered by the dearth of relevant disease models. Despite numerous animal models, significant challenges remain in...
2.
Yasmin I, Dharmarajan A, Warrier S
Biochim Biophys Acta Mol Cell Res
. 2025 Feb;
1872(3):119918.
PMID: 39938692
Wnt/β-catenin pathway dysregulation is associated with glioblastoma multiforme (GBM) pathogenesis and Wnt antagonists are downregulated in GBM. Wnt antagonist secreted frizzled-related protein 4 (sFRP4) has a tissue-specific, anti-metastatic and anti-stemness...
3.
Advances and challenges in therapeutic resistant biomarkers of neuroblastoma: A comprehensive review
Y K, Arjunan A, Maigandan D, Dharmarajan A, Perumalsamy L
Biochim Biophys Acta Rev Cancer
. 2024 Nov;
1879(6):189222.
PMID: 39577750
Therapeutic resistance is one of the significant challenges in Neuroblastoma. Owing to its molecular diversity, the therapeutic resistance mechanisms of Neuroblastoma are highly complicated. The traditional chemo and radio therapeutics...
4.
Bhagtaney L, Dharmarajan A, Warrier S
Cancers (Basel)
. 2024 Mar;
16(5).
PMID: 38473318
Carcinogenesis is a complex process characterized by intricate changes in organ histology, biochemistry, epigenetics, and genetics. Within this intricate landscape, cancer stem cells (CSCs) have emerged as distinct cell types...
5.
Ganesan S, Dharmarajan A, Sudhir G, Perumalsamy L
Mol Neurobiol
. 2024 Feb;
61(10):7661-7679.
PMID: 38421469
Spinal cord injury (SCI) is a complex neurodegenerative pathology that consistently harbours a poor prognostic outcome. At present, there are few therapeutic strategies that can halt neuronal cell death and...
6.
Singh P, Murali R, Shanmugam S, Thomas S, Scott J, Warrier S, et al.
Stem Cells
. 2024 Jan;
42(3):200-215.
PMID: 38167958
Leukemogenesis is a complex process that involves multiple stages of mutation in either hematopoietic stem or progenitor cells, leading to cancer development over time. Acute myeloid leukemia (AML) is an...
7.
Peri S, Y K, Hubert T, Rajaraman R, Arfuso F, Sundaram S, et al.
Cancers (Basel)
. 2023 Dec;
15(24).
PMID: 38136392
Cancer therapeutics face significant challenges due to drug resistance and tumour recurrence. The tumour microenvironment (TME) is a crucial contributor and essential hallmark of cancer. It encompasses various components surrounding...
8.
Soundararajan L, Warrier S, Dharmarajan A, Bhaskaran N
J Cell Biochem
. 2023 Nov;
125(1):3-21.
PMID: 37997702
Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. The concept of ROS and...
9.
Mankuzhy P, Dharmarajan A, Perumalsamy L, Sharun K, Samji P, Dilley R
Tissue Cell
. 2023 Oct;
85:102240.
PMID: 37879288
Development, growth, and remodeling of blood vessels occur through an intricate process involving cell differentiation, proliferation, and rearrangement by cell migration under the direction of various signaling pathways. Recent reports...
10.
Gamit N, Patil M, B Sundrappa S, Sundaram S, Sethi G, Dharmarajan A, et al.
Drug Dev Res
. 2023 Aug;
84(7):1496-1512.
PMID: 37571798
A reliable and efficient in vitro model is needed to screen drugs for Alzheimer's disease (AD), as many drugs are currently in the developmental stage. To address this, we developed...