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Arturo Simoni-Nieves

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Articles 18
Citations 179
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Recent Articles
1.
Simoni-Nieves A, Lindzen M, Giri S, Gupta N, Chatterjee R, Selvadurai B, et al.
Cell Rep Med . 2024 Aug; 5(9):101703. PMID: 39216477
Activating EGFR (epidermal growth factor receptor) mutations can be inhibited by specific tyrosine kinase inhibitors (TKIs), which have changed the landscape of lung cancer therapy. However, due to secondary mutations...
2.
Rastovic U, Bozzano S, Riva A, Simoni-Nieves A, Harris N, Miquel R, et al.
Int J Mol Sci . 2024 Jan; 25(1). PMID: 38203321
Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite the global burden of ALD, there is a...
3.
Marrocco I, Giri S, Simoni-Nieves A, Gupta N, Rudnitsky A, Haga Y, et al.
Cell Rep Med . 2023 Aug; 4(8):101142. PMID: 37557179
EGFR-specific tyrosine kinase inhibitors (TKIs), especially osimertinib, have changed lung cancer therapy, but secondary mutations confer drug resistance. Because other EGFR mutations promote dimerization-independent active conformations but L858R strictly depends...
4.
Noronha A, Nataraj N, Lee J, Zhitomirsky B, Oren Y, Oster S, et al.
Cancer Discov . 2022 Jul; 12(11):2666-2683. PMID: 35895872
Significance: EGFR-mutant lung cancers treated with kinase inhibitors often evolve resistance due to secondary mutations. We report that in similarity to the bacterial SOS response stimulated by antibiotics, endogenous mutators...
5.
Salas-Silva S, Lopez-Ramirez J, Barrera-Chimal J, Lazzarini-Lechuga R, Simoni-Nieves A, Souza V, et al.
Life Sci . 2022 Feb; 295:120423. PMID: 35196530
Hepatocyte growth factor (HGF) has been proved to protect the liver against α-naphthylisothiocyanate (ANIT)-induced cholestasis by acting as an antioxidant agent and redirecting toxic biliary solutes towards blood for urinary...
6.
Salas-Silva S, Simoni-Nieves A, Chavez-Rodriguez L, Gutierrez-Ruiz M, Bucio L, Quiroz L
Ann Hepatol . 2021 Sep; 26:100530. PMID: 34509686
The mechanism of damage of the biliary epithelium remains partially unexplored. However, recently many works have offered new evidence regarding the cholangiocytes' damage process, which is the main target in...
7.
Simoni-Nieves A, Salas-Silva S, Chavez-Rodriguez L, Escobedo-Calvario A, Desoteux M, Bucio L, et al.
Cancers (Basel) . 2021 Apr; 13(7). PMID: 33917315
Non-alcoholic fatty liver disease (NAFLD) and progression to non-alcoholic steatohepatitis (NASH) result as a consequence of diverse conditions, mainly unbalanced diets. Particularly, high-fat and cholesterol content, as well as carbohydrates,...
8.
Simoni-Nieves A, Clavijo-Cornejo D, Salas-Silva S, Escobedo-Calvario A, Bucio L, Souza V, et al.
Ann Hepatol . 2021 Mar; 25:100339. PMID: 33675999
Introduction And Objectives: It is well-known that signaling mediated by the hepatocyte growth factor (HGF) and its receptor c-Met in the liver is involved in the control of cellular redox...
9.
Gil-Hernandez A, Arroyo-Campuzano M, Simoni-Nieves A, Zazueta C, Gomez-Quiroz L, Silva-Palacios A
Front Cell Dev Biol . 2021 Jan; 8:622215. PMID: 33511135
Membrane contact sites (MCS) are typically defined as areas of proximity between heterologous or homologous membranes characterized by specific proteins. The study of MCS is considered as an emergent field...
10.
Hernandez S, Simoni-Nieves A, Gerardo-Ramirez M, Torres S, Fucho R, Gonzalez J, et al.
J Cell Physiol . 2020 Nov; 236(5):4076-4090. PMID: 33174245
Growth differentiation factor 11 (GDF11) has been characterized as a key regulator of differentiation in cells that retain stemness features. Recently, it has been reported that GDF11 exerts tumor-suppressive properties...