Arto T Pulliainen
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Explore the profile of Arto T Pulliainen including associated specialties, affiliations and a list of published articles.
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36
Citations
594
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Recent Articles
11.
Sakari M, Laisi A, Pulliainen A
ACS Infect Dis
. 2022 Jan;
8(3):433-456.
PMID: 35099182
The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is...
12.
Kling C, Pulliainen A, Barth H, Ernst K
Toxins (Basel)
. 2021 Aug;
13(7).
PMID: 34357952
causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor. PT is an AB-type toxin, and consists of the enzymatic...
13.
Ernst K, Mittler A, Winkelmann V, Kling C, Eberhardt N, Anastasia A, et al.
Sci Rep
. 2021 Mar;
11(1):5429.
PMID: 33686161
Whooping cough is caused by Bordetella pertussis that releases pertussis toxin (PT) which comprises enzyme A-subunit PTS1 and binding/transport B-subunit. After receptor-mediated endocytosis, PT reaches the endoplasmic reticulum from where...
14.
Paramonov V, Sahlgren C, Rivero-Muller A, Pulliainen A
ACS Sens
. 2020 Nov;
5(11):3438-3448.
PMID: 33147407
Detection of pertussis toxin (PTX) activity is instrumental for the development and manufacturing of pertussis vaccines. These quality and safety measures require thousands of mice annually. Here, we describe nterference...
15.
Eskonen V, Tong-Ochoa N, Mattsson L, Miettinen M, Lastusaari M, Pulliainen A, et al.
Anal Chem
. 2020 Sep;
92(19):13202-13210.
PMID: 32872778
Post-translational modifications (PTMs) are one of the most important regulatory mechanisms in cells, and they play key roles in cell signaling both in health and disease. PTM catalyzing enzymes have...
16.
Ojala V, Knittle A, Kirjalainen P, Merilahti J, Kortesoja M, Tvorogov D, et al.
J Biol Chem
. 2020 Jun;
295(33):11559-11571.
PMID: 32561640
ERBB4 is a member of the epidermal growth factor receptor (EGFR)/ERBB subfamily of receptor tyrosine kinases that regulates cellular processes including proliferation, migration, and survival. ERBB4 signaling is involved in...
17.
Kopra K, Vuorinen E, Abreu-Blanco M, Wang Q, Eskonen V, Gillette W, et al.
Anal Chem
. 2020 Feb;
92(7):4971-4979.
PMID: 32106676
We have developed a rapid and sensitive single-well dual-parametric method introduced in linked RAS nucleotide exchange and RAS/RAF-RBD interaction assays. RAS mutations are frequent drivers of multiple different human cancers,...
18.
Ashok Y, Miettinen M, Oliveira D, Tamirat M, Nareoja K, Tiwari A, et al.
ACS Infect Dis
. 2020 Jan;
6(4):588-602.
PMID: 31899865
The targeted pathogen-selective approach to drug development holds promise to minimize collateral damage to the beneficial microbiome. The AB-topology pertussis toxin (PtxS1-S5) is a major virulence factor of , the...
19.
Miettinen M, Vedantham M, Pulliainen A
Microbes Infect
. 2019 Jun;
21(10):423-431.
PMID: 31207286
Protein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to perturbation of cell signaling. This review summarizes the emerging data indicating that host...
20.
Regier Y, Komma K, Weigel M, Pulliainen A, Gottig S, Hain T, et al.
Front Microbiol
. 2019 Jan;
9:3100.
PMID: 30619179
The deer ked () is distributed in Europe, North America, and Siberia and mainly infests cervids as roe deer, fallow deer, and moose. From a one health perspective, deer keds...