Arthur P H de Jong
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Explore the profile of Arthur P H de Jong including associated specialties, affiliations and a list of published articles.
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12
Citations
978
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Recent Articles
1.
Droogers W, Willems J, MacGillavry H, de Jong A
eNeuro
. 2022 Jul;
PMID: 35851300
CRISPR/Cas9-mediated knock-in methods enable the labeling of individual endogenous proteins to faithfully determine their spatiotemporal distribution in cells. However, reliable multiplexing of knock-in events in neurons remains challenging because of...
2.
Willems J, de Jong A, Scheefhals N, Mertens E, Catsburg L, Poorthuis R, et al.
PLoS Biol
. 2020 Apr;
18(4):e3000665.
PMID: 32275651
The correct subcellular distribution of proteins establishes the complex morphology and function of neurons. Fluorescence microscopy techniques are invaluable to investigate subcellular protein distribution, but they suffer from the limited...
3.
Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba M, et al.
Neuron
. 2019 Jun;
103(2):217-234.e4.
PMID: 31171447
Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are...
4.
de Jong A, Roggero C, Ho M, Wong M, Brautigam C, Rizo J, et al.
Neuron
. 2018 Apr;
98(2):335-349.e7.
PMID: 29606581
Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca channels, and the presence of the phospholipid PIP in the target membrane. Although...
5.
de Jong A, Meijer M, Saarloos I, Cornelisse L, Toonen R, Sorensen J, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(18):5095-100.
PMID: 27091977
Presynaptic activation of the diacylglycerol (DAG)/protein kinase C (PKC) pathway is a central event in short-term synaptic plasticity. Two substrates, Munc13-1 and Munc18-1, are essential for DAG-induced potentiation of vesicle...
6.
de Jong A, Fioravante D
Front Cell Neurosci
. 2014 Nov;
8:356.
PMID: 25400547
The complex manner in which patterns of presynaptic neural activity are translated into short-term plasticity (STP) suggests the existence of multiple presynaptic calcium (Ca(2+)) sensors, which regulate the amplitude and...
7.
de Jong A, Schmitz S, Toonen R, Verhage M
J Cell Biol
. 2012 Apr;
197(2):327-37.
PMID: 22492722
Different regulatory principles influence synaptic coupling between neurons, including positional principles. In dendrites of pyramidal neurons, postsynaptic sensitivity depends on synapse location, with distal synapses having the highest gain. In...
8.
Schmitz S, Hjorth J, Joemai R, Wijntjes R, Eijgenraam S, de Bruijn P, et al.
J Neurosci Methods
. 2010 Dec;
195(2):185-93.
PMID: 21167201
The shape, structure and connectivity of nerve cells are important aspects of neuronal function. Genetic and epigenetic factors that alter neuronal morphology or synaptic localization of pre- and post-synaptic proteins...
9.
Groffen A, Martens S, Arazola R, Cornelisse L, Lozovaya N, de Jong A, et al.
Science
. 2010 Feb;
327(5973):1614-8.
PMID: 20150444
Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence...
10.
Ruano D, Abecasis G, Glaser B, Lips E, Cornelisse L, de Jong A, et al.
Am J Hum Genet
. 2010 Jan;
86(2):113-25.
PMID: 20060087
Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of...