Arsalan U Syed
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Explore the profile of Arsalan U Syed including associated specialties, affiliations and a list of published articles.
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11
Citations
209
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Recent Articles
1.
Flores-Tamez V, Martin-Aragon Baudel M, Hong J, Taylor J, Ren L, Le T, et al.
J Am Heart Assoc
. 2024 Oct;
13(20):e035375.
PMID: 39377203
Background: Increased vascular Ca1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are...
2.
Huang L, Cheng F, Zhang X, Zielonka J, Nystoriak M, Xiang W, et al.
Sci Adv
. 2023 May;
9(21):eade7280.
PMID: 37235659
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*), we show decreased arteriolar tone in vivo during brain AVM...
3.
Prada M, Syed A, Reddy G, Martin-Aragon Baudel M, Flores-Tamez V, Sasse K, et al.
Nat Commun
. 2020 Oct;
11(1):5303.
PMID: 33082339
The L-type Ca channel Ca1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca channel via PKA, but the underlying...
4.
Syed A, Reddy G, Ghosh D, Prada M, Nystoriak M, Morotti S, et al.
J Clin Invest
. 2019 Jun;
129(8):3140-3152.
PMID: 31162142
Elevated blood glucose (hyperglycemia) is a hallmark metabolic abnormality in diabetes. Hyperglycemia is associated with protein kinase A (PKA)-mediated stimulation of L-type Ca2+ channels in arterial myocytes resulting in increased...
5.
Prada M, Syed A, Buonarati O, Reddy G, Nystoriak M, Ghosh D, et al.
Elife
. 2019 Mar;
8.
PMID: 30821687
Elevated glucose increases vascular reactivity by promoting L-type Ca1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a G-coupled P2Y...
6.
Syed A, Koide M, Brayden J, Wellman G
J Cereb Blood Flow Metab
. 2017 Dec;
39(4):670-679.
PMID: 29260608
Activation of ATP-sensitive potassium (K) channels in arterial smooth muscle (ASM) contributes to vasodilation evoked by a variety of endogenous and exogenous compounds. Although controversial, activation of K channels by...
7.
Nieves-Cintron M, Syed A, Buonarati O, Rigor R, Nystoriak M, Ghosh D, et al.
Sci Rep
. 2017 Oct;
7(1):14058.
PMID: 29070899
Large-conductance Ca-activated potassium (BK) channels are key determinants of vascular smooth muscle excitability. Impaired BK channel function through remodeling of BK β1 expression and function contributes to vascular complications in...
8.
Nieves-Cintron M, Syed A, Nystoriak M, Navedo M
Microcirculation
. 2017 Oct;
25(1).
PMID: 29044853
Voltage-gated potassium (K ) channels are key regulators of vascular smooth muscle contractility and vascular tone, and thus have major influence on the microcirculation. K channels are important determinants of...
9.
Koide M, Syed A, Braas K, May V, Wellman G
J Mol Neurosci
. 2014 Apr;
54(3):443-50.
PMID: 24744252
Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent vasodilator of numerous vascular beds, including cerebral arteries. Although PACAP-induced cerebral artery dilation is suggested to be cyclic AMP (cAMP)-dependent, the...
10.
Syed A, Koide M, Braas K, May V, Wellman G
J Mol Neurosci
. 2012 Jul;
48(3):574-83.
PMID: 22766684
Migraine is a debilitating neurological disorder characterized by mild to severe headache that is often accompanied by aura and other neurological symptoms. Among proposed mechanisms, dilation of the dural vasculature...