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Arnold Kahn

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Recent Articles
1.
Lang S, Hilsabeck T, Wilson K, Sharma A, Bose N, Brackman D, et al.
PLoS Genet . 2019 Aug; 15(8):e1008318. PMID: 31415568
Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA...
2.
Chaudhuri J, Bains Y, Guha S, Kahn A, Hall D, Bose N, et al.
Cell Metab . 2018 Sep; 28(3):337-352. PMID: 30184484
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and peptides/proteins are an inevitable component of the aging process in all eukaryotic organisms, including humans. To date, a substantial...
3.
Zee T, Bose N, Zee J, Beck J, Yang S, Parihar J, et al.
Nat Med . 2017 Feb; 23(3):288-290. PMID: 28165480
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at...
4.
Chi T, Kim M, Lang S, Bose N, Kahn A, Flechner L, et al.
PLoS One . 2015 May; 10(5):e0124150. PMID: 25970330
Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown. Given its importance in seemingly divergent disease processes,...
5.
Blaschko S, Chi T, Miller J, Flechner L, Fakra S, Kapahi P, et al.
J Urol . 2012 Dec; 189(2):735-9. PMID: 23260568
Purpose: Strontium has chemical similarity to calcium, which enables the replacement of calcium by strontium in biomineralization processes. Incorporating strontium into human bone and teeth has been studied extensively but...
6.
Blaschko S, Miller J, Chi T, Flechner L, Fakra S, Kahn A, et al.
J Urol . 2012 Oct; 189(2):726-34. PMID: 23021997
Purpose: Common methods of commercial urolithiasis analysis, such as light microscopy and Fourier transform infrared spectroscopy, provide limited or no information on the molecular composition of stones, which is vital...
7.
Reiner A, Kahn A, Eisner B, Pletcher M, Sadetsky N, Williams O, et al.
J Urol . 2011 Jan; 185(3):920-5. PMID: 21251678
Purpose: Recent reports suggest that nephrolithiasis and atherosclerosis share a number of risk factors. To our knowledge there has been no previous examination of the relationship between kidney stones and...
8.
Kahn A
Ageing Res Rev . 2010 May; 10(2):179-80. PMID: 20452463
The Longevity Consortium is a multi-investigator, multi-institutional research group focused on identifying the genetic variants that regulate human lifespan and healthy aging. The text that follows is an introduction to...
9.
Kahn A, Olsen A
Dose Response . 2010 Mar; 8(1):48-52. PMID: 20221288
Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in...
10.
Calvanese V, Lara E, Kahn A, Fraga M
Ageing Res Rev . 2009 Sep; 8(4):268-76. PMID: 19716530
The role of epigenetics in aging and age-related diseases is a key issue in molecular physiology and medicine because certain epigenetic factors are thought to mediate, at least in part,...