The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2018 Sep 6

PMID 30184484

Citations 229

Authors

Jyotiska Chaudhuri

Yasmin Bains

Sanjib Guha

Arnold Kahn

David Hall

Neelanjan Bose

Alejandro Gugliucci

Pankaj Kapahi

Affiliations

Soon will be listed here.

Abstract

Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and peptides/proteins are an inevitable component of the aging process in all eukaryotic organisms, including humans. To date, a substantial body of evidence shows that AGEs and their functionally compromised adducts are linked to and perhaps responsible for changes seen during aging and for the development of many age-related morbidities. However, much remains to be learned about the biology of AGE formation, causal nature of these associations, and whether new interventions might be developed that will prevent or reduce the negative impact of AGEs-related damage. To facilitate achieving these latter ends, we show how invertebrate models, notably Drosophila melanogaster and Caenorhabditis elegans, can be used to explore AGE-related pathways in depth and to identify and assess drugs that will mitigate against the detrimental effects of AGE-adduct development.

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