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Arne Mueller

Explore the profile of Arne Mueller including associated specialties, affiliations and a list of published articles. Areas
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Citations 277
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Recent Articles
11.
Lemmens M, Fischer B, Zogg M, Rodrigues L, Kerr G, Del Rio-Espinola A, et al.
Mol Ther Methods Clin Dev . 2021 Oct; 23:241-253. PMID: 34703845
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity...
12.
Mueller A, Paterson E, McIntosh A, Praestgaard J, Bylo M, Hoefling H, et al.
Ann Clin Transl Neurol . 2021 Aug; 8(9):1845-1856. PMID: 34355532
Background: Friedreich's ataxia is an inherited, progressive, neurodegenerative disease that typically begins in childhood. Disease severity is commonly assessed with rating scales, such as the modified Friedreich's Ataxia Rating Scale,...
13.
Rochester L, Mazza C, Mueller A, Caulfield B, McCarthy M, Becker C, et al.
Digit Biomark . 2021 Jan; 4(Suppl 1):13-27. PMID: 33442578
Health care has had to adapt rapidly to COVID-19, and this in turn has highlighted a pressing need for tools to facilitate remote visits and monitoring. Digital health technology, including...
14.
Mueller A, Hoefling H, Nuritdinow T, Holway N, Schieker M, Daumer M, et al.
Digit Biomark . 2020 Feb; 2(2):79-89. PMID: 32095759
Continuous patient activity monitoring during rehabilitation, enabled by digital technologies, will allow the objective capture of real-world mobility and aligning treatment to each individual's recovery trajectory in real time. To...
15.
Mueller A, Hoefling H, Muaremi A, Praestgaard J, Walsh L, Bunte O, et al.
JMIR Mhealth Uhealth . 2019 Nov; 7(11):e15191. PMID: 31774406
Background: Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health-relevant data from patients. However, only limited data and results have been published that demonstrate...
16.
Vitobello A, Perner J, Beil J, Zhu J, Del Rio-Espinola A, Morawiec L, et al.
Life Sci Alliance . 2019 Oct; 2(5). PMID: 31615920
Liver cancer susceptibility varies amongst humans and between experimental animal models because of multiple genetic and epigenetic factors. The molecular characterization of such susceptibilities has the potential to enhance cancer...
17.
Keppler A, Nuritidinow T, Mueller A, Hoefling H, Schieker M, Clay I, et al.
PLoS One . 2019 Aug; 14(8):e0221732. PMID: 31469864
Background: Mobile accelerometry is a powerful and promising option to capture long-term changes in gait in both clinical and real-world scenarios. Increasingly, gait parameters have demonstrated their value as clinical...
18.
Levell J, Caferro T, Chenail G, Dix I, Dooley J, Firestone B, et al.
ACS Med Chem Lett . 2017 Feb; 8(2):151-156. PMID: 28197303
High throughput screening and subsequent hit validation identified 4-isopropyl-3-(2-((1-phenylethyl)amino)pyrimidin-4-yl)oxazolidin-2-one as a potent inhibitor of IDH1. Synthesis of the four separate stereoisomers identified the (,)-diastereomer (, ) as the most potent...
19.
Wark S, MacPhail C, McKay K, Mueller A
Aust Health Rev . 2016 Aug; 41(4):436-442. PMID: 27537279
Objective The aim of the present study was to explore the use of complementary consent methodologies to support a potentially vulnerable group of people, namely those aging with intellectual disability,...
20.
Brasa S, Mueller A, Jacquemont S, Hahne F, Rozenberg I, Peters T, et al.
Clin Epigenetics . 2016 Feb; 8:15. PMID: 26855684
Background: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The...