Ariosto S Silva
Overview
Explore the profile of Ariosto S Silva including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
27
Citations
1047
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
21.
Silva A, Kam Y, Khin Z, Minton S, Gillies R, Gatenby R
Cancer Res
. 2012 Oct;
72(24):6362-70.
PMID: 23066036
Many cancers adapt to chemotherapeutic agents by upregulating membrane efflux pumps that export drugs from the cytoplasm, but this response comes at an energetic cost. In breast cancer patients, expression...
22.
Silva A, Gatenby R
Mol Pharm
. 2011 Oct;
8(6):2012-20.
PMID: 21958215
Aberrant mutations of centrocytes in germinal centers (GC) can generate two completely different diseases: B-cell lymphomas and monoclonal gammopathy of undetermined significance (MGUS). In this article we use computational models...
23.
Lee H, Silva A, Concilio S, Li Y, Slifker M, Gatenby R, et al.
Cancer Res
. 2011 Aug;
71(20):6327-37.
PMID: 21859828
Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fitness of...
24.
Silva A, Gatenby R
Biol Direct
. 2010 Apr;
5:25.
PMID: 20406443
Background: Disseminated cancer remains a nearly uniformly fatal disease. While a number of effective chemotherapies are available, tumors inevitably evolve resistance to these drugs ultimately resulting in treatment failure and...
25.
Silva A, Gatenby R, Gillies R, Yunes J
J Theor Biol
. 2009 Nov;
262(4):601-13.
PMID: 19887072
Mathematical models and clinical observations have demonstrated that microenvironmental hypoxia and acidosis are important selection factors during the later stages of the somatic evolution of breast cancer. The consequent promotion...
26.
Gatenby R, Silva A, Gillies R, Frieden B
Cancer Res
. 2009 Jun;
69(11):4894-903.
PMID: 19487300
A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy frequently fails due to emergence of resistant populations. The...
27.
Silva A, Yunes J, Gillies R, Gatenby R
Cancer Res
. 2009 Mar;
69(6):2677-84.
PMID: 19276380
A number of studies have shown that the extracellular pH (pHe) in cancers is typically lower than that in normal tissue and that an acidic pHe promotes invasive tumor growth...