Ariel Feiglin
Overview
Explore the profile of Ariel Feiglin including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
361
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0
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Recent Articles
1.
Dadush A, Merdler-Rabinowicz R, Gorelik D, Feiglin A, Buchumenski I, Pal L, et al.
NPJ Genom Med
. 2024 Feb;
9(1):16.
PMID: 38409211
The majority of human genetic diseases are caused by single nucleotide variants (SNVs) in the genome sequence. Excitingly, new genomic techniques known as base editing have opened efficient pathways to...
2.
Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, et al.
Clin Cancer Res
. 2024 Feb;
30(9):1889-1905.
PMID: 38381406
Purpose: Resistance to endocrine therapy (ET) and CDK4/6 inhibitors (CDK4/6i) is a clinical challenge in estrogen receptor (ER)-positive (ER+) breast cancer. Cyclin-dependent kinase 7 (CDK7) is a candidate target in...
3.
Reich T, Adato O, Kofman N, Feiglin A, Unger R
Sci Rep
. 2023 Mar;
13(1):5125.
PMID: 36991078
No abstract available.
4.
Reich T, Adato O, Kofman N, Feiglin A, Unger R
Sci Rep
. 2023 Jan;
13(1):482.
PMID: 36627355
Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) is a membrane protein expressed on immune cells, involved in neurodegenerative diseases and cancer. Recently, it was shown that TREM2 is expressed...
5.
Nardone A, Qiu X, Spisak S, Nagy Z, Feiglin A, Feit A, et al.
Cancer Res
. 2022 Aug;
82(20):3673-3686.
PMID: 35950920
Significance: A unique FOXA1-ER axis in invasive lobular breast cancer promotes disease progression and tamoxifen resistance, highlighting a potential therapeutic avenue for clinical investigations dedicated to this disease. See related...
6.
Buchumenski I, Roth S, Kopel E, Katsman E, Feiglin A, Levanon E, et al.
Genome Res
. 2021 Oct;
31(12):2354-2361.
PMID: 34667118
Base editors are dedicated engineered deaminases that enable directed conversion of specific bases in the genome or transcriptome in a precise and efficient manner, and hold promise for correcting pathogenic...
7.
Biber G, Ben-Shmuel A, Noy E, Joseph N, Puthenveetil A, Reiss N, et al.
Nat Commun
. 2021 Sep;
12(1):5581.
PMID: 34552085
Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant functions including activation, proliferation, migration and invasiveness. Wiskott-Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor and is...
8.
Qiu X, Feit A, Feiglin A, Xie Y, Kesten N, Taing L, et al.
Genomics Proteomics Bioinformatics
. 2021 Jul;
19(4):652-661.
PMID: 34284136
Chromatin immunoprecipitation sequencing (ChIP-seq) and the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) have become essential technologies to effectively measure protein-DNA interactions and chromatin accessibility. However, there is a...
9.
Tsivion-Visbord H, Kopel E, Feiglin A, Sofer T, Barzilay R, Ben-Zur T, et al.
Nat Commun
. 2020 Oct;
11(1):5236.
PMID: 33067431
The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here...
10.
Jagtap S, Thanos J, Fu T, Wang J, Lalonde J, Dial T, et al.
Hum Mol Genet
. 2019 Sep;
28(21):3625-3636.
PMID: 31518399
The X-linked neurodevelopmental diseases CDKL5 deficiency disorder (CDD) and Rett syndrome (RTT) are associated with intellectual disability, infantile spasms and seizures. Although mitochondrial dysfunction has been suggested in RTT, less...