Ariadne L Hager-Theodorides
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Explore the profile of Ariadne L Hager-Theodorides including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hager-Theodorides A, Furmanski A, Ross S, Outram S, Rowbotham N, Crompton T
J Immunol
. 2009 Aug;
183(5):3023-32.
PMID: 19667090
The Hedgehog (Hh) responsive transcription factor Gli3 is required for efficient thymocyte development in the fetus. In this study we show that Gli3, not detected in adult thymocytes, is expressed...
12.
Rowbotham N, Hager-Theodorides A, Furmanski A, Ross S, Outram S, Dessens J, et al.
Blood
. 2009 Mar;
113(21):5144-56.
PMID: 19273836
Hedgehog signaling regulates differentiation, survival, and proliferation of the earliest double-negative (DN) thymocytes, but its importance at later stages of T-cell development is controversial. Here we use loss- and gain-of-function...
13.
Outram S, Hager-Theodorides A, Shah D, Rowbotham N, Drakopoulou E, Ross S, et al.
Blood
. 2008 Dec;
113(10):2217-28.
PMID: 19109233
We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh(-/-) thymi had reduced differentiation to double-positive (DP) cell...
14.
Outram S, Gordon A, Hager-Theodorides A, Metcalfe J, Crompton T, Kemp P
Cell Cycle
. 2008 Jul;
7(13):2047-55.
PMID: 18604172
The Kruppel-like factor, KLF13, is a member of a family of transcription factors shown to be involved in haematopoietic development. Here we show that KLF13 is involved in the development...
15.
Rowbotham N, Furmanski A, Hager-Theodorides A, Ross S, Drakopoulou E, Koufaris C, et al.
Cell Cycle
. 2008 Apr;
7(7):904-8.
PMID: 18414059
Hedgehog proteins signal for differentiation, survival and proliferation of the earliest thymocyte progenitors, but their functions at later stages of thymocyte development and in peripheral T-cell function are controversial. Here...
16.
Gordon A, Outram S, Keramatipour M, Goddard C, Colledge W, Metcalfe J, et al.
J Biol Chem
. 2008 Feb;
283(18):11897-904.
PMID: 18285334
To study the function of the Krüppel-like transcription factor KLF13 in vivo, we generated mice with a disrupted Klf13 allele. Although Klf13(-/-) mice are viable, fewer mice were present at...
17.
Rowbotham N, Hager-Theodorides A, Furmanski A, Crompton T
Cell Cycle
. 2007 Sep;
6(17):2138-42.
PMID: 17786048
The Hedgehog (Hh) signaling pathway is a key regulator of both embryonic development and homeostasis of adult tissues, including thymus and blood. In the thymus, Hh signals for differentiation, survival...
18.
Crompton T, Outram S, Hager-Theodorides A
Nat Rev Immunol
. 2007 Aug;
7(9):726-35.
PMID: 17690714
The production of mature functional T cells in the thymus requires signals from the thymic epithelium. Here, we review recent experiments showing that one way in which the epithelium controls...
19.
Hager-Theodorides A, Rowbotham N, Outram S, Dessens J, Crompton T
Eur J Immunol
. 2007 Feb;
37(2):487-500.
PMID: 17273993
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage. Thymocyte development in adult Rag1, Rag2...
20.
Rowbotham N, Hager-Theodorides A, Cebecauer M, Shah D, Drakopoulou E, Dyson J, et al.
Blood
. 2007 Jan;
109(9):3757-66.
PMID: 17227833
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in...