Archibald S Perkins
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Explore the profile of Archibald S Perkins including associated specialties, affiliations and a list of published articles.
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29
Citations
987
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Recent Articles
1.
Koh C, Bahirvani A, Wang C, Yokomizo T, Ng C, Du L, et al.
Gene
. 2022 Nov;
851:147049.
PMID: 36384171
A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation...
2.
Zhang Y, McGrath K, Ayoub E, Kingsley P, Yu H, Fegan K, et al.
Cell Rep
. 2021 Aug;
36(7):109562.
PMID: 34407416
Hematopoietic ontogeny consists of two broad programs: an initial hematopoietic stem cell (HSC)-independent program followed by HSC-dependent hematopoiesis that sequentially seed the fetal liver and generate blood cells. However, the...
3.
McGlynn K, Sun R, Vonica A, Rudzinskas S, Zhang Y, Perkins A
Exp Hematol
. 2020 May;
85:20-32.e3.
PMID: 32437910
Mds1-Evi1 (also known as Prdm3) and Prdm16 are two highly related zinc finger transcription factors that, within the hematopoietic system, are both expressed primarily in hematopoietic stem cells (HSCs). Our...
4.
Christodoulou C, Spencer J, Yeh S, Turcotte R, Kokkaliaris K, Panero R, et al.
Nature
. 2020 Feb;
578(7794):278-283.
PMID: 32025033
The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions. It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs...
5.
Frisch B, Hoffman C, Latchney S, LaMere M, Myers J, Ashton J, et al.
JCI Insight
. 2019 Apr;
5.
PMID: 30998506
The bone marrow microenvironment (BMME) contributes to the regulation of hematopoietic stem cell (HSC) function, though its role in age-associated lineage skewing is poorly understood. Here we show that dysfunction...
6.
Ayoub E, Wilson M, McGrath K, Li A, Frisch B, Palis J, et al.
Nat Commun
. 2018 Oct;
9(1):4239.
PMID: 30315161
Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which...
7.
8.
Fenouille N, Bassil C, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, et al.
Nat Med
. 2017 Feb;
23(3):301-313.
PMID: 28191887
Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloid leukemia (AML) and is associated with poor clinical outcome. Here,...
9.
Wilson M, Tsakraklides V, Tran M, Xiao Y, Zhang Y, Perkins A
J Biol Chem
. 2016 Apr;
291(26):13591-607.
PMID: 27129260
One mechanism by which oncoproteins work is through perturbation of cellular maturation; understanding the mechanisms by which this occurs can lead to the development of targeted therapies. EVI1 is a...
10.
Bard-Chapeau E, Szumska D, Jacob B, Chua B, Chatterjee G, Zhang Y, et al.
PLoS One
. 2014 Mar;
9(2):e89397.
PMID: 24586749
The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1...