Aprile L Pilon
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Explore the profile of Aprile L Pilon including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
338
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Recent Articles
1.
Rojas-Quintero J, Laucho-Contreras M, Wang X, Fucci Q, Burkett P, Kim S, et al.
JCI Insight
. 2023 Feb;
8(6).
PMID: 36787195
Low Club Cell 16 kDa protein (CC16) plasma levels are linked to accelerated lung function decline in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke-exposed (CS-exposed) Cc16-/- mice have...
2.
Kimura S, Yokoyama S, Pilon A, Kurotani R
Pharmacol Ther
. 2022 Jan;
236:108112.
PMID: 35016921
Secretoglobin (SCGB) 3A2 was first identified in 2001 as a protein exhibiting similarities in amino acid sequence and gene structure to SCGB1A1, a multi-functional cytokine-like molecule highly expressed in airway...
3.
Yokoyama S, Nakayama S, Xu L, Pilon A, Kimura S
Cell Death Discov
. 2021 Jan;
7(1):12.
PMID: 33452234
Non-canonical inflammasome activation that recognizes intracellular lipopolysaccharide (LPS) causes pyroptosis, the inflammatory death of innate immune cells. The role of pyroptosis in innate immune cells is to rapidly eliminate pathogen-infected...
4.
Johnson M, Younis U, Menghani S, Addison K, Whalen M, Pilon A, et al.
Am J Respir Crit Care Med
. 2020 Dec;
203(11):1410-1418.
PMID: 33326355
CC16 (club cell secretory protein) is a pneumoprotein produced predominantly by pulmonary club cells. Circulating CC16 is associated with protection from the inception and progression of the two most common...
5.
Davis J, Pilon A, Shenberger J, Breeze J, Terrin N, Mazela J, et al.
Pediatr Res
. 2019 May;
86(2):254-260.
PMID: 31086287
Background: Preterm neonates can develop chronic pulmonary insufficiency of prematurity (CPIP) later in infancy. Recombinant human CC10 protein (rhCC10) is an anti-inflammatory agent that could potentially prevent CPIP. Methods: The...
6.
Lopez E, Fujiwara O, Nelson C, Winn M, Clayton R, Cox R, et al.
Shock
. 2019 May;
53(3):317-326.
PMID: 31045988
Objectives: To evaluate the dose effects of Recombinant human Club cell 10-kDa protein (rhCC10) on lung function in a well-characterized ovine model of acute respiratory distress syndrome (ARDS) induced by...
7.
Yokoyama S, Cai Y, Murata M, Tomita T, Yoneda M, Xu L, et al.
Elife
. 2018 Dec;
7.
PMID: 30526845
Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression of some tumors,...
8.
Gorji N, Pilon A, Winn M, Newsome M, Davis J
Neonatology
. 2016 Dec;
111(3):247-252.
PMID: 27902984
Background: The club cell 10-kDa protein (CC10) is a homeostatic protein that is produced in the lung, diffuses into the blood, and is then excreted into the urine and stool....
9.
Laucho-Contreras M, Polverino F, Gupta K, Taylor K, Kelly E, Pinto-Plata V, et al.
Eur Respir J
. 2015 Feb;
45(6):1544-56.
PMID: 25700379
Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We measured...
10.
Cai Y, Winn M, Zehmer J, Gillette W, Lubkowski J, Pilon A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2013 Nov;
306(1):L10-22.
PMID: 24213919
Secretoglobin (SCGB) 3A2 is a member of the SCGB gene superfamily of small secreted proteins, predominantly expressed in lung airways. We hypothesize that human SCGB3A2 may exhibit anti-inflammatory, growth factor,...