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April Nettesheim

Explore the profile of April Nettesheim including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 113
Followers 0
Related Specialties
General Medicine
Cell Biology
Science
Top 10 Co-Authors
Myoung Sup Shim
Paloma B Liton
Angela Dixon
Haiyan Gong
Aislyn Coyne
Chien-Chia Su
Joshua Hirt
W Daniel Stamer
Kristin M Perkumas
Molly Walsh
Published In
Autophagy Rep
Autophagy
J Clin Med
Sci Rep
Proc Natl Acad Sci U S A
Affiliations
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Recent Articles
1.
Autophagy deficiency protects against ocular hypertension and glaucoma
Dixon A, Shim M, Nettesheim A, Coyne A, Su C, Gong H, et al.
Autophagy Rep . 2024 Dec; 3(1). PMID: 39726939
Glaucoma encompasses a spectrum of disorders characterized by the chronic degeneration of retinal ganglion cell (RGC) axons and the progressive loss of RGCs, resulting in visual impairment. In this study,...
2.
Shear stress induces autophagy in Schlemm's canal cells via primary cilia-mediated SMAD2/3 signaling pathway
Shim M, Dixon A, Nettesheim A, Perkumas K, Stamer W, Sun Y, et al.
Autophagy Rep . 2023 Aug; 2(1). PMID: 37637387
The Schlemm's canal (SC) is a circular, lymphatic-like vessel located at the limbus of the eye that participates in the regulation of aqueous humor drainage to control intraocular pressure (IOP)....
3.
Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontanous glaucoma mouse models
Dixon A, Shim M, Nettesheim A, Coyne A, Su C, Gong H, et al.
Cell Death Dis . 2023 Aug; 14(8):554. PMID: 37620383
Glaucoma is a group of diseases that leads to chronic degeneration of retinal ganglion cell (RGC) axons and progressive loss of RGCs, resulting in vision loss. While aging and elevated...
4.
Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells
Shim M, Nettesheim A, Dixon A, Liton P
Proc Natl Acad Sci U S A . 2021 Mar; 118(13). PMID: 33753495
Activation of autophagy is one of the responses elicited by high intraocular pressure (IOP) and mechanical stretch in trabecular meshwork (TM) cells. However, the mechanosensor and the molecular mechanisms by...
5.
Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma
Nettesheim A, Shim M, Dixon A, Raychaudhuri U, Gong H, Liton P
J Clin Med . 2020 Dec; 10(1). PMID: 33379277
Extracellular matrix (ECM) deposition in the trabecular meshwork (TM) is one of the hallmarks of glaucoma, a group of human diseases and leading cause of permanent blindness. The molecular mechanisms...
6.
Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model
Nettesheim A, Dixon A, Shim M, Coyne A, Walsh M, Liton P
Invest Ophthalmol Vis Sci . 2020 Aug; 61(10):31. PMID: 32797200
Purpose: To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods: Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected...
7.
Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells
Nettesheim A, Shim M, Hirt J, Liton P
Sci Rep . 2019 Nov; 9(1):16092. PMID: 31695131
The trabecular meshwork (TM) is a specialized ocular tissue, which is responsible, together with the Schlemm's canal (SC), for maintaining appropriate levels of intraocular pressure. Dysfunction of these tissues leads...
8.
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress
Shim M, Nettesheim A, Hirt J, Liton P
Autophagy . 2019 Sep; 16(7):1248-1261. PMID: 31476975
Abbreviation: AdGFP: adenovirus encoding GFP; ATG: autophagy-related; BSA: bovine serum albumin; CMS: cyclic mechanical stretch; Co-IP: coimmunoprecipitation; DAPI: 4',6-diamidino-2-phenylindole; DFCs: dense fibrillar components; EM: electron microscopy; FCs: fibrillar centers; GCs:...