Apoorva K Iyengar
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Explore the profile of Apoorva K Iyengar including associated specialties, affiliations and a list of published articles.
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10
Citations
479
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Recent Articles
1.
Beaman M, Yin W, Smith A, Sears P, Leigh M, Ferkol T, et al.
Am J Med Genet A
. 2024 Oct;
197(2):e63880.
PMID: 39364610
Variation in the non-coding genome represents an understudied mechanism of disease and it remains challenging to predict if single nucleotide variants, small insertions and deletions, or structural variants in non-coding...
2.
Brotman S, Raulerson C, Vadlamudi S, Currin K, Shen Q, Parsons V, et al.
Am J Hum Genet
. 2022 Jan;
109(1):66-80.
PMID: 34995504
Alternate splicing events can create isoforms that alter gene function, and genetic variants associated with alternate gene isoforms may reveal molecular mechanisms of disease. We used subcutaneous adipose tissue of...
3.
Miller D, Sulovari A, Wang T, Loucks H, Hoekzema K, Munson K, et al.
Am J Hum Genet
. 2021 Jul;
108(8):1436-1449.
PMID: 34216551
Despite widespread clinical genetic testing, many individuals with suspected genetic conditions lack a precise diagnosis, limiting their opportunity to take advantage of state-of-the-art treatments. In some cases, testing reveals difficult-to-evaluate...
4.
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Vinuela A, Varshney A, van de Bunt M, Prasad R, Asplund O, Bennett A, et al.
Nat Commun
. 2020 Oct;
11(1):4912.
PMID: 32999275
Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from...
5.
Spracklen C, Iyengar A, Vadlamudi S, Raulerson C, Jackson A, Brotman S, et al.
PLoS Genet
. 2020 Sep;
16(9):e1009019.
PMID: 32915782
Loci identified in genome-wide association studies (GWAS) can include multiple distinct association signals. We sought to identify the molecular basis of multiple association signals for adiponectin, a hormone involved in...
6.
Spracklen C, Horikoshi M, Kim Y, Lin K, Bragg F, Moon S, et al.
Nature
. 2020 Jun;
582(7811):240-245.
PMID: 32499647
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D); however, most of these loci have been identified in analyses...
7.
Raffield L, Iyengar A, Wang B, Gaynor S, Spracklen C, Zhong X, et al.
Am J Hum Genet
. 2019 Dec;
106(1):112-120.
PMID: 31883642
Whole-genome sequencing (WGS) can improve assessment of low-frequency and rare variants, particularly in non-European populations that have been underrepresented in existing genomic studies. The genetic determinants of C-reactive protein (CRP),...
8.
Davis J, Vadlamudi S, Roman T, Zeynalzadeh M, Iyengar A, Mohlke K
Hum Mol Genet
. 2018 Nov;
28(6):888-895.
PMID: 30445632
Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are heritable risk factors for cardiovascular disease, yet the molecular mechanisms underlying the majority of blood lipid-associated genome-wide association studies signals remain...
9.
Schmidt S, Dorsett C, Iyengar A, Frohlich F
Cereb Cortex
. 2016 Sep;
27(9):4396-4410.
PMID: 27578493
Cortical oscillations modulate cellular excitability and facilitate neuronal communication and information processing. Layer 5 pyramidal cells (L5 PYs) drive low-frequency oscillations (<4 Hz) in neocortical networks in vivo. In vitro,...
10.
Schmidt S, Iyengar A, Foulser A, Boyle M, Frohlich F
Brain Stimul
. 2014 Aug;
7(6):878-89.
PMID: 25129402
Background: Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation modality that may modulate cognition by enhancing endogenous neocortical oscillations by application of sine-wave electric fields. Yet, the role...