Aparna Vasanthakumar
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Explore the profile of Aparna Vasanthakumar including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Garza K, Clarke S, Ho Y, Bruss M, Vasanthakumar A, Anderson S, et al.
Metallomics
. 2020 Dec;
12(12):2186-2198.
PMID: 33325950
Iron regulatory proteins (IRPs) are iron-responsive RNA binding proteins that dictate changes in cellular iron metabolism in animal cells by controlling the fate of mRNAs containing iron responsive elements (IREs)....
12.
Vasanthakumar A, Davis J, Idler K, Waring J, Asque E, Riley-Gillis B, et al.
Clin Epigenetics
. 2020 Jun;
12(1):84.
PMID: 32539856
Background: Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallmark symptoms...
13.
Vasanthakumar A, Davis J, Abunimeh M, Soderholm J, Zha J, Dumas E, et al.
PLoS One
. 2018 Jun;
13(5):e0198296.
PMID: 29851985
Background: Genetic variants of inosine triphosphatase (ITPA) that confer reduced ITPase activity are associated with protection against ribavirin(RBV)-induced hemolytic anemia in peginterferon(IFN)/RBV-based treatment of hepatitis C virus (HCV). Patients with...
14.
Vasanthakumar A, Godley L
Cancer Genet
. 2016 Apr;
209(4):177.
PMID: 27085961
No abstract available.
15.
Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, et al.
Blood
. 2015 Dec;
127(3):310-3.
PMID: 26644450
BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break...
16.
Vasanthakumar A, Zullow H, Lepore J, Thomas K, Young N, Anastasi J, et al.
Stem Cells
. 2015 Sep;
33(12):3643-54.
PMID: 26417967
Epigenetic alterations play a central role in the control of normal and malignant blood cell development. We demonstrate here that expression of a truncated DNA methyltransferase 3B isoform DNMT3B7, which...
17.
Dominguez P, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, et al.
Cell Rep
. 2015 Sep;
12(12):2086-98.
PMID: 26365193
Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated...
18.
Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, et al.
Cancer Res
. 2015 May;
75(14):2833-43.
PMID: 25972343
TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well as other covalently modified cytosines and its mutations are common in myeloid leukemia. However, the exact mechanism and the extent to which...
19.
Vasanthakumar A, Godley L
Cancer Genet
. 2015 Apr;
208(5):167-77.
PMID: 25892122
Emerging data have demonstrated that 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) play unique roles in several biological processes, including the control of gene...
20.
Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, et al.
Cell Rep
. 2014 Dec;
9(5):1841-1855.
PMID: 25482556
Somatic mutations in IDH1/IDH2 and TET2 result in impaired TET2-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The observation that WT1 inactivating mutations anticorrelate with TET2/IDH1/IDH2 mutations in acute myeloid...