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Anuhar Chaturvedi

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Articles 31
Citations 1115
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Recent Articles
1.
Stadler C, Ellinghaus U, Fischer L, Bahr-Mahmud H, Rao M, Lindemann C, et al.
Sci Transl Med . 2024 May; 16(748):eadl2720. PMID: 38776391
We present the preclinical pharmacology of BNT142, a lipid nanoparticle (LNP)-formulated RNA (RNA-LNP) encoding a T cell-engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds...
2.
Bahr-Mahmud H, Ellinghaus U, Stadler C, Fischer L, Lindemann C, Chaturvedi A, et al.
Oncoimmunology . 2023 Oct; 12(1):2255041. PMID: 37860278
IMAB362/Zolbetuximab, a first-in-class IgG1 antibody directed against the cancer-associated gastric-lineage marker CLDN18.2, has recently been reported to have met its primary endpoint in two phase 3 trials as a first-line...
3.
Yang M, Pan Z, Huang K, Busche G, Liu H, Gohring G, et al.
Leukemia . 2021 Nov; 36(3):675-686. PMID: 34732858
With an incidence of ~50%, the absence or reduced protein level of p53 is much more common than TP53 mutations in acute myeloid leukemia (AML). AML with FLT3-ITD (internal tandem...
4.
Arora S, Joshi G, Chaturvedi A, Heuser M, Patil S, Kumar R
J Med Chem . 2021 Nov; 65(2):1171-1205. PMID: 34726055
The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in...
5.
Kusuma M, Arora S, Kalra S, Chaturvedi A, Heuser M, Kumar R
Curr Top Med Chem . 2021 Aug; 21(25):2258-2271. PMID: 34348626
Introduction: Pyruvate kinase isozyme M2 (PKM2) was observed to be overexpressed and play a key role in cell growth and cancer cells' metabolism. During the past years, phytochemicals have been...
6.
Heuser M, Heida B, Buttner K, Wienecke C, Teich K, Funke C, et al.
Blood Adv . 2021 Apr; 5(9):2294-2304. PMID: 33929500
Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and prognostic prior to allogeneic hematopoietic cell transplantation (alloHCT). We evaluated the...
7.
Berger R, Wachsmuth C, Waldhier M, Renner-Sattler K, Thomas S, Chaturvedi A, et al.
Cancers (Basel) . 2021 Apr; 13(8). PMID: 33916994
In recent years, onco-metabolites like D-2-hydroxyglutarate, which is produced in isocitrate dehydrogenase-mutated tumors, have gained increasing interest. Here, we report a metabolite in human specimens that is closely related to...
8.
Kattih B, Shirvani A, Klement P, Garrido A, Gabdoulline R, Liebich A, et al.
Leukemia . 2020 Sep; 35(5):1301-1316. PMID: 32948843
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to leukemia gene mutations and associates with an increased risk for coronary artery disease and poor prognosis in ischemic cardiomyopathy. Two recurrently...
9.
Gupta C, Kaulfuss S, Gorlich K, Othman B, Chaturvedi A, Heuser M
Ann Hematol . 2020 Apr; 99(6):1415-1417. PMID: 32296913
No abstract available.
10.
Chaturvedi A, Gupta C, Gabdoulline R, Borchert N, Goparaju R, Kaulfuss S, et al.
Haematologica . 2020 Apr; 106(2):565-573. PMID: 32241846
Mutant IDH1 (mIDH1) inhibitors have shown single-agent activity in relapsed/refractory AML, though most patients eventually relapse. We evaluated the efficacy and molecular mechanism of the combination treatment with azacitidine, which...