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Antony J Fairbanks

Explore the profile of Antony J Fairbanks including associated specialties, affiliations and a list of published articles. Areas
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Articles 82
Citations 594
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Recent Articles
1.
Singh G, Wilson F, Reid N, Fairbanks A
Carbohydr Res . 2025 Feb; 551:109411. PMID: 39922129
A one-step reaction for the production of unprotected glycosyl C-sulfonates directly from reducing sugars in aqueous solution has been developed, avoiding the use of any protecting groups. The reaction is...
2.
Talukdar R, Chong D, Fairbanks A
Org Lett . 2024 Nov; 26(49):10536-10541. PMID: 39602555
Unprotected sugars are converted directly into their corresponding dihydropyridine esters, which can be activated under photoredox conditions to produce glycosyl radicals, which in turn can react with a range of...
3.
Ishii N, Mascherpa A, Fairbanks A
Carbohydr Res . 2024 Nov; 547:109327. PMID: 39580870
A deprotected biantennary high mannose heptasaccharide N-glycan comprising two mannose-6-phosphate residues was synthesised as a putative ligand for the mannose 6-phosphate receptors, using a convergent [3 + 4] glycosylation strategy.
4.
Qiu X, Chong D, Fairbanks A
Org Lett . 2023 Mar; 25(11):1989-1993. PMID: 36912487
Unprotected sugars are selectively acetylated simply by stirring in aqueous solution in the presence of acetic anhydride and a weak base such as sodium carbonate. The reaction is selective for...
5.
Mascherpa A, Ishii N, Tayagui A, Liu J, Sollogoub M, Fairbanks A
Chemistry . 2022 Oct; 29(4):e202203252. PMID: 36265126
β-Cyclodextrin (β-CD) and derivatives are approved therapeutics in >30 clinical settings. β-CDs have also shown promise as therapeutics for treatment of some lysosomal storage disorders, such as Niemann-Pick disease type...
6.
Qiu X, Garden A, Fairbanks A
Chem Sci . 2022 Apr; 13(14):4122-4130. PMID: 35440979
Unprotected 2-acetamido sugars may be directly converted into their oxazolines using 2-chloro-1,3-dimethylimidazolinium chloride (DMC), and a suitable base, in aqueous solution. Freeze drying and acid catalysed reaction with an alcohol...
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8.
Arif T, Currie M, Dobson R, Newson H, Poonthiyil V, Fairbanks A, et al.
Carbohydr Res . 2021 Oct; 510:108445. PMID: 34607125
The synthesis of analogues of natural enzyme substrates can be used to help deduce enzymatic mechanisms. N-Acetylmannosamine-6-phosphate 2-epimerase is an enzyme in the bacterial sialic acid catabolic pathway. To investigate...
9.
Lasse M, Stampfli A, Orban T, Bothara R, Gerrard J, Fairbanks A, et al.
Biochim Biophys Acta Gen Subj . 2021 Sep; 1865(12):130013. PMID: 34534644
Background: Lipid hydroperoxides decompose to reactive aldehydes, such as acrolein. Measurement of oxidative stress markers in the clinic could improve risk stratification for patients. Methods: To aid the development of...
10.
Currie M, Manjunath L, Horne C, Rendle P, Subramanian R, Friemann R, et al.
J Biol Chem . 2021 Aug; 297(4):101113. PMID: 34437902
There are five known general catalytic mechanisms used by enzymes to catalyze carbohydrate epimerization. The amino sugar epimerase N-acetylmannosamine-6-phosphate 2-epimerase (NanE) has been proposed to use a deprotonation-reprotonation mechanism, with...