Antonius W M Boersma
Overview
Explore the profile of Antonius W M Boersma including associated specialties, affiliations and a list of published articles.
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13
Citations
677
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Recent Articles
1.
Uhr K, Prager-van der Smissen W, Heine A, Ozturk B, van Jaarsveld M, Boersma A, et al.
PLoS One
. 2019 May;
14(5):e0216400.
PMID: 31063487
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited number of...
2.
Nyhan M, ODonovan T, Boersma A, Wiemer E, McKenna S
BMC Cancer
. 2016 Feb;
16:101.
PMID: 26878873
Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells...
3.
van Jaarsveld M, van Kuijk P, Boersma A, Helleman J, van IJcken W, Mathijssen R, et al.
Mol Cancer
. 2015 Nov;
14:196.
PMID: 26576679
Background: Drug resistance hampers the efficient treatment of malignancies, including advanced stage ovarian cancer, which has a 5-year survival rate of only 30 %. The molecular processes underlying resistance have...
4.
Burger H, den Dekker A, Segeletz S, Boersma A, de Bruijn P, Debiec-Rychter M, et al.
Mol Pharmacol
. 2015 Jun;
88(3):477-87.
PMID: 26108972
The intracellular uptake and retention (IUR) of imatinib is reported to be controlled by the influx transporter SLC22A1 (organic cation transporter 1). We recently hypothesized that alternative uptake and/or retention...
5.
van Jaarsveld M, Wouters M, Boersma A, Smid M, van IJcken W, Mathijssen R, et al.
Mol Oncol
. 2014 Jan;
8(3):458-68.
PMID: 24462518
The DNA damage response (DDR) is activated upon DNA damage and prevents accumulation of mutations and chromosomal rearrangements, both driving carcinogenesis. Tumor cells often have defects in the DDR, which...
6.
Gits C, van Kuijk P, Jonkers M, Boersma A, Smid M, van IJcken W, et al.
Int J Cancer
. 2013 Dec;
135(2):348-61.
PMID: 24375455
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into four histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy,...
7.
Riaz M, van Jaarsveld M, Hollestelle A, Prager-van der Smissen W, Heine A, Boersma A, et al.
Breast Cancer Res
. 2013 Apr;
15(2):R33.
PMID: 23601657
Introduction: Breast cancer is a genetically and phenotypically complex disease. To understand the role of miRNAs in this molecular complexity, we performed miRNA expression analysis in a cohort of molecularly...
8.
van Jaarsveld M, Blijdorp I, Boersma A, Pothof J, Mathijssen R, Verweij J, et al.
Eur J Cancer
. 2012 Oct;
49(2):345-51.
PMID: 23041051
Platinum-based chemotherapy (e.g. cisplatin, carboplatin) is standard of care for many types of cancer including ovarian cancer, however, the efficacy of treatment is hampered by the development of therapy resistance....
9.
Foekens J, Sieuwerts A, Smid M, Look M, de Weerd V, Boersma A, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(35):13021-6.
PMID: 18755890
In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER(+)) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic...
10.
Helleman J, Burger H, Hamelers I, Boersma A, de Kroon A, Stoter G, et al.
Cancer Biol Ther
. 2006 Jun;
5(8):943-9.
PMID: 16775422
The effectiveness of platinum drugs in the treatment of cancer is hindered by intrinsic and acquired resistance. The cause of clinical resistance to platinum compounds is still unknown. In an...