Antonio Filareto
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Explore the profile of Antonio Filareto including associated specialties, affiliations and a list of published articles.
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21
Citations
467
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Recent Articles
1.
Nolt G, Keeble A, Wen Y, Strong A, Thomas N, Valentino T, et al.
Geroscience
. 2023 Oct;
46(2):2153-2176.
PMID: 37872294
Skeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with advanced age. The accumulation of senescent cells, along with...
2.
Pharaoh G, Ostrom E, Stuppard R, Campbell M, Borghardt J, Franti M, et al.
Redox Biol
. 2023 Jun;
64:102770.
PMID: 37295159
It is unclear whether mitochondrial dysfunction and redox stress contribute to impaired age-related muscle regenerative capacity. Here we characterized a novel compound, BI4500, that inhibits the release of reactive oxygen...
3.
Lin B, Shin J, Jeffreys W, Wang N, Lukban C, Moorer M, et al.
JCI Insight
. 2022 Sep;
7(19).
PMID: 36099033
Gene mutations causing loss of dystrophin result in the severe muscle disease known as Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair, DMD therapy remains largely palliative. Loss of...
4.
Dungan C, Murach K, Zdunek C, Tang Z, Nolt G, Brightwell C, et al.
Aging Cell
. 2021 Dec;
21(1):e13528.
PMID: 34904366
Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood. We hypothesized that senolytic drugs...
5.
Biressi S, Filareto A, Rando T
J Clin Invest
. 2020 Sep;
130(11):5652-5664.
PMID: 32946430
Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation of different therapeutic options, a definitive treatment has...
6.
Ho P, Lahey L, Mourkioti F, Kraft P, Filareto A, Brandt M, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(39):E9182-E9191.
PMID: 30181272
In gene therapy for Duchenne muscular dystrophy there are two potential immunological obstacles. An individual with Duchenne muscular dystrophy has a genetic mutation in dystrophin, and therefore the wild-type protein...
7.
Filareto A, Maguire-Nguyen K, Gan Q, Aldanondo G, Machado L, Chamberlain J, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(30):7741-7746.
PMID: 29987034
Duchenne muscular dystrophy (DMD) is a rare, muscle degenerative disease resulting from the absence of the dystrophin protein. DMD is characterized by progressive loss of muscle fibers, muscle weakness, and...
8.
Chan S, Arpke R, Filareto A, Xie N, Pappas M, Penaloza J, et al.
Cell Stem Cell
. 2018 Jul;
23(1):74-85.e6.
PMID: 29979993
Derivation of functional skeletal muscle stem cells from pluripotent cells without genetic modification has proven elusive. Here we show that teratomas formed in adult skeletal muscle differentiate in vivo to...
9.
Houang E, Haman K, Filareto A, Perlingeiro R, Bates F, Lowe D, et al.
Mol Ther Methods Clin Dev
. 2015 Dec;
2:15042.
PMID: 26623440
Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration. A unique therapeutic approach for DMD is the use of synthetic membrane stabilizers to protect the fragile dystrophic...
10.
Filareto A, Rinaldi F, Arpke R, Darabi R, Belanto J, Toso E, et al.
Skelet Muscle
. 2015 Oct;
5:36.
PMID: 26504514
Background: Satellite cells (SCs) are indispensable for muscle regeneration and repair; however, due to low frequency in primary muscle and loss of engraftment potential after ex vivo expansion, their use...