Anton Bittner
Overview
Explore the profile of Anton Bittner including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1435
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0
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Recent Articles
1.
Coe K, Feinstein M, Higgins J, Leung P, Scott B, Skaptason J, et al.
Drug Metab Dispos
. 2022 Jun;
50(8):1064-1076.
PMID: 35680134
[4-(4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] (JNJ-2482272), under investigation as an anti-inflammatory agent, was orally administered to rats once daily at 60 mg/kg for 6 consecutive days. Despite high plasma exposure after single administration (C...
2.
Wiegman C, Michaeloudes C, Haji G, Narang P, Clarke C, Russell K, et al.
J Allergy Clin Immunol
. 2015 Apr;
136(3):769-80.
PMID: 25828268
Background: Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in driving the oxidative stress-induced pathology. Objective: We...
3.
Soroosh P, Wu J, Xue X, Song J, Sutton S, Sablad M, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(33):12163-8.
PMID: 25092323
The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17-producing CD4(+) Th17 T cells, which are essential in host defense and may play key pathogenic...
4.
Zhao S, Fung-Leung W, Bittner A, Ngo K, Liu X
PLoS One
. 2014 Jan;
9(1):e78644.
PMID: 24454679
To demonstrate the benefits of RNA-Seq over microarray in transcriptome profiling, both RNA-Seq and microarray analyses were performed on RNA samples from a human T cell activation experiment. In contrast...
5.
Arndt G, Dossey L, Cullen L, Lai A, Druker R, Eisbacher M, et al.
BMC Cancer
. 2009 Oct;
9:374.
PMID: 19843336
Background: MicroRNAs (MiRNAs) are short non-coding RNAs that control protein expression through various mechanisms. Their altered expression has been shown to be associated with various cancers. The aim of this...
6.
Meurers B, Dziewczapolski G, Shi T, Bittner A, Kamme F, Shults C
J Neurosci
. 2009 May;
29(21):6828-39.
PMID: 19474310
Functional alterations in striatal projection neurons play a critical role in the development of motor symptoms in Parkinson's disease (PD), but their molecular adaptation to dopamine depletion remains poorly understood....
7.
Meurers B, Dziewczapolski G, Bittner A, Shi T, Kamme F, Shults C
Neurobiol Dis
. 2009 Mar;
34(1):178-88.
PMID: 19320057
Motor symptoms in Parkinson's disease (PD) are associated with complex changes of firing properties in basal ganglia output neurons (BGON). The abnormalities are generally attributed to altered synaptic input and...
8.
Dorai H, Li K, Huang C, Bittner A, Galindo J, Carmen A
Biotechnol Prog
. 2007 Jun;
23(4):911-20.
PMID: 17592857
Manufacturing cell line development involves transfection of therapeutic antibody genes into host cell lines and isolation of primary transfectomas that upon subcloning yield high expressing cell lines secreting the desired...
9.
Nie A, McMillian M, Parker J, Leone A, Bryant S, Yieh L, et al.
Mol Carcinog
. 2006 Aug;
45(12):914-33.
PMID: 16921489
Toxicogenomics technology defines toxicity gene expression signatures for early predictions and hypotheses generation for mechanistic studies, which are important approaches for evaluating toxicity of drug candidate compounds. A large gene...
10.
McMillian M, Nie A, Parker J, Leone A, Kemmerer M, Bryant S, et al.
Toxicol Appl Pharmacol
. 2005 Jun;
207(2 Suppl):171-8.
PMID: 15982685
Macrophage activators (MA), peroxisome proliferators (PP), and oxidative stressors/reactive metabolites (OS/RM) all produce oxidative stress and hepatotoxicity in rats. However, these three classes of hepatotoxicants give three distinct gene transcriptional...