Annie Jen
Overview
Explore the profile of Annie Jen including associated specialties, affiliations and a list of published articles.
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13
Citations
19
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Recent Articles
1.
Khana D, Jen A, Shishkova E, Thusoo E, Williams J, Henkel A, et al.
bioRxiv
. 2025 Feb;
PMID: 39974948
Thermodynamically constrained reactions and pathways are hypothesized to impose greater protein demands on cells, requiring higher enzyme amounts to sustain a given flux compared to those with stronger thermodynamics. To...
2.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
Sci Adv
. 2025 Jan;
11(4):eadu5787.
PMID: 39841834
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
3.
Barten L, Crandall J, Xie D, Serate J, Handowski E, Jen A, et al.
bioRxiv
. 2025 Jan;
PMID: 39829844
Biofuels derived from renewable and sustainable lignocellulosic biomass, such as switchgrass, offer a promising means to limit greenhouse gas emissions. However, switchgrass grown under drought conditions contains high levels of...
4.
Ma M, Dubey R, Jen A, Pusapati G, Singal B, Shishkova E, et al.
Science
. 2024 Nov;
386(6722):667-672.
PMID: 39509507
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeeping function, we identified...
5.
Kodali S, Proietti L, Valcarcel G, Lopez-Rubio A, Pessina P, Eder T, et al.
Nat Cell Biol
. 2024 Aug;
26(10):1745-1758.
PMID: 39169219
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through...
6.
Balnis J, Tufts A, Jackson E, Drake L, Singer D, Lacomis D, et al.
Sci Adv
. 2024 Aug;
10(34):eado8549.
PMID: 39167644
Reduced skeletal muscle mass and oxidative capacity coexist in patients with pulmonary emphysema and are independently associated with higher mortality. If reduced cellular respiration contributes to muscle atrophy in that...
7.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585873
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
8.
Mori H, Peterson S, Simmermon R, Overmyer K, Nishii A, Paulsson E, et al.
Mol Metab
. 2024 Mar;
83:101916.
PMID: 38492843
Objective: Exposure of adipocytes to 'cool' temperatures often found in the periphery of the body induces expression of Stearoyl-CoA Desaturase-1 (Scd1), an enzyme that converts saturated fatty acids to monounsaturated...
9.
Duerre D, Hansen J, John S, Jen A, Carrillo N, Bui H, et al.
bioRxiv
. 2023 Dec;
PMID: 38076785
With age, people tend to accumulate body fat and reduce energy expenditure . Brown (BAT) and beige adipose tissue dissipate heat and increase energy expenditure via the activity of the...
10.
Mori H, Peterson S, Simmermon R, Overmyer K, Nishii A, Paulsson E, et al.
bioRxiv
. 2023 Nov;
PMID: 37961537
Exposure of adipocytes to 'cool' temperatures often found in the periphery of the body induces expression of Stearoyl-CoA Desaturase-1 (SCD1), an enzyme that converts saturated fatty acids to monounsaturated fatty...