Anne Osbourn
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Explore the profile of Anne Osbourn including associated specialties, affiliations and a list of published articles.
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103
Citations
4667
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Recent Articles
1.
Courdavault V, Osbourn A
Curr Opin Plant Biol
. 2024 Dec;
83:102673.
PMID: 39689377
No abstract available.
2.
Spence P, Reed J, Osbourn A
PLoS Biol
. 2024 Nov;
22(11):e3002886.
PMID: 39499679
Genomics-based predictions indicate that plants harbor the ability to make a vast array of as yet undiscovered chemistry. Recent advances open up the potential to harness this capability at unprecedented...
3.
Goddard Z, Searcey M, Osbourn A
Trends Pharmacol Sci
. 2024 Oct;
45(11):964-968.
PMID: 39482199
Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and...
4.
Hodgson H, Stephenson M, Kikuchi S, Martin L, Liu J, Casson R, et al.
J Am Chem Soc
. 2024 Oct;
146(43):29305-29310.
PMID: 39418479
The furan ring is a defining feature of limonoids, a class of highly rearranged and bioactive plant tetranortriterpenoids. We recently reported an apparent complete biosynthetic pathway to these important natural...
5.
Ma A, Sun J, Feng L, Xue Z, Wu W, Song B, et al.
New Phytol
. 2024 Oct;
244(6):2430-2441.
PMID: 39400347
Triterpene skeletons, catalyzing by 2,3-oxidosqualene cyclases (OSCs), are essential for synthesis of steroids and triterpenoids. In japonica rice cultivars Zhonghua11, a total of 12 OsOSCs have been found. While the...
6.
Ji W, Osbourn A, Liu Z
Philos Trans R Soc Lond B Biol Sci
. 2024 Sep;
379(1914):20230359.
PMID: 39343032
Plants are chemical engineers par excellence. Collectively they make a vast array of structurally diverse specialized metabolites. The raw materials for building new pathways (genes encoding biosynthetic enzymes) are commonly...
7.
Jo S, El-Demerdash A, Owen C, Srivastava V, Wu D, Kikuchi S, et al.
Nat Chem Biol
. 2024 Jul;
21(2):215-226.
PMID: 39043959
Soapwort (Saponaria officinalis) is a flowering plant from the Caryophyllaceae family with a long history of human use as a traditional source of soap. Its detergent properties are because of...
8.
Liu Y, Zhao X, Gan F, Chen X, Deng K, Crowe S, et al.
Nature
. 2024 May;
629(8013):937-944.
PMID: 38720067
QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans. However, owing to the complex structure of QS-21, its...
9.
Martin L, Kikuchi S, Rejzek M, Owen C, Reed J, Orme A, et al.
Nat Chem Biol
. 2024 Jan;
20(4):493-502.
PMID: 38278997
QS-21 is a potent vaccine adjuvant currently sourced by extraction from the Chilean soapbark tree. It is a key component of human vaccines for shingles, malaria, coronavirus disease 2019 and...
10.
Polturak G, Misra R, El-Demerdash A, Owen C, Steed A, McDonald H, et al.
Nat Commun
. 2023 Nov;
14(1):6977.
PMID: 37914713
Isoflavones are a group of phenolic compounds mostly restricted to plants of the legume family, where they mediate important interactions with plant-associated microbes, including in defense from pathogens and in...