Annabel H A Parret
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Explore the profile of Annabel H A Parret including associated specialties, affiliations and a list of published articles.
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16
Citations
384
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Recent Articles
1.
Beckham K, Staack S, Wilmanns M, Parret A
Protein Sci
. 2020 Oct;
29(12):2528-2537.
PMID: 33006405
Structural and biophysical characterization of molecular mechanisms of disease-causing pathogens, such as Mycobacterium tuberculosis, often requires recombinant expression of large amounts highly pure protein. For the production of mycobacterial proteins,...
2.
Freire D, Gutierrez C, Garza-Garcia A, Grabowska A, Sala A, Ariyachaokun K, et al.
Mol Cell
. 2019 Feb;
73(6):1282-1291.e8.
PMID: 30792174
Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin,...
3.
Tuukkanen A, Freire D, Chan S, Arbing M, Reed R, Evans T, et al.
J Mol Biol
. 2018 Nov;
431(2):289-307.
PMID: 30419243
Type VII secretion systems (ESX) are responsible for transport of multiple proteins in mycobacteria. How different ESX systems achieve specific secretion of cognate substrates remains elusive. In the ESX systems,...
4.
Beckham K, Ciccarelli L, Bunduc C, Mertens H, Ummels R, Lugmayr W, et al.
Nat Microbiol
. 2017 Apr;
2:17047.
PMID: 28394313
Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids. To transport substrates across this complex cell envelope, mycobacteria rely on type VII (also known as...
5.
Milewski M, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, et al.
Proteomics Clin Appl
. 2016 Jul;
10(9-10):1049-1057.
PMID: 27400835
Purpose: Tuberculosis is still a major threat to global health. New tools and strategies to produce disease-related proteins are quintessential for the development of novel vaccines and diagnostic markers. Experimental...
6.
Korotkova N, Freire D, Phan T, Ummels R, Creekmore C, Evans T, et al.
Mol Microbiol
. 2014 Aug;
94(2):367-82.
PMID: 25155747
The growth or virulence of Mycobacterium tuberculosis bacilli depends on homologous type VII secretion systems, ESX-1, ESX-3 and ESX-5, which export a number of protein effectors across membranes to the...
7.
Daleke M, van der Woude A, Parret A, Ummels R, de Groot A, Watson D, et al.
J Biol Chem
. 2012 Jul;
287(38):31939-47.
PMID: 22843727
Mycobacteria use the dedicated type VII protein secretion systems ESX-1 and ESX-5 to secrete virulence factors across their highly hydrophobic cell envelope. The substrates of these systems include the large...
8.
Parret A, Temmerman K, De Mot R
Appl Environ Microbiol
. 2005 Sep;
71(9):5197-207.
PMID: 16151105
Bacteriocin LlpA, produced by Pseudomonas sp. strain BW11M1, is a peculiar antibacterial protein due to its homology to mannose-binding lectins mostly found in monocots (A. H. A. Parret, G. Schoofs,...
9.
Estrada de Los Santos P, Parret A, De Mot R
FEMS Microbiol Lett
. 2005 Mar;
244(2):243-50.
PMID: 15766775
Pseudomonas sp. BW11M1 produces a novel type of bacteriocin that inhibits the growth of Pseudomonas putida GR12-2R3 and some phytopathogenic fluorescent Pseudomonas. A collection of mutants was screened for altered...
10.
Parret A, Wyns L, De Mot R, Loris R
Acta Crystallogr D Biol Crystallogr
. 2004 Sep;
60(Pt 10):1922-4.
PMID: 15388953
LlpA is a bacteriocin produced by Pseudomonas sp. BW11M1 that shows remarkable similarity to a family of mannose-binding plant lectins. A His-tagged version of LlpA was recombinantly produced in Escherichia...