Anna Wiles
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Explore the profile of Anna Wiles including associated specialties, affiliations and a list of published articles.
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11
Citations
243
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Recent Articles
1.
The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
Kazantseva M, Mehta S, Eiholzer R, Gimenez G, Bowie S, Campbell H, et al.
Cell Death Dis
. 2019 Aug;
10(9):631.
PMID: 31431617
Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β isoform characterize...
2.
Kazantseva M, Mehta S, Eiholzer R, Hung N, Wiles A, Slatter T, et al.
Mamm Genome
. 2018 Jul;
29(11-12):831-842.
PMID: 29992419
This review paper outlines studies on the Δ122p53 mouse, a model of the human Δ133p53 isoform, together with studies in other model organisms, cell culture, and where available, clinical investigations....
3.
Campbell H, Fleming N, Roth I, Mehta S, Wiles A, Williams G, et al.
Nat Commun
. 2018 Jan;
9(1):254.
PMID: 29343721
∆122p53 mice (a model of ∆133p53 isoform) are tumour-prone, have extensive inflammation and elevated serum IL-6. To investigate the role of IL-6 we crossed ∆122p53 mice with IL-6 null mice....
4.
Thompson C, Wiles A, Poole C, Knight M
FASEB J
. 2015 Oct;
30(2):716-26.
PMID: 26499268
Lithium chloride (LiCl) exhibits significant therapeutic potential as a treatment for osteoarthritis. Hedgehog signaling is activated in osteoarthritis, where it promotes chondrocyte hypertrophy and cartilage matrix catabolism. Hedgehog signaling requires...
5.
Vermunt J, Fraser M, Herbison P, Wiles A, Schlup M, Schultz M
World J Gastroenterol
. 2015 Sep;
21(35):10224-33.
PMID: 26401088
Aim: To determine the prevalence of infection with hepatitis C virus (HCV) in those most at risk of advanced liver disease and to identify gaps in knowledge of HCV. Methods:...
6.
Thompson C, Yasmin H, Varone A, Wiles A, Poole C, Knight M
J Orthop Res
. 2015 Jul;
33(10):1552-9.
PMID: 26174175
Osteoarthritis is a chronic degenerative disease that affects the articular cartilage. Recent studies have demonstrated that lithium chloride exhibits significant efficacy as a chondroprotective agent, blocking cartilage degradation in response...
7.
Hung N, Chen Y, Taha A, Olivecrona M, Boet R, Wiles A, et al.
BMC Cancer
. 2014 Mar;
14:159.
PMID: 24602166
Background: The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by...
8.
Woolley A, Algie M, Samuel W, Harfoot R, Wiles A, Hung N, et al.
PLoS One
. 2011 Jun;
6(6):e20603.
PMID: 21695211
The literature concerning the subcellular location of Y-box binding protein 1 (YB-1), its abundance in normal and cancer tissues, and its prognostic significance is replete with inconsistencies. An explanation for...
9.
Slatter T, Gifford-Garner J, Wiles A, Tan X, Chen Y, MacFarlane M, et al.
Am J Pathol
. 2010 Nov;
177(6):2694-700.
PMID: 21037079
Telomere maintenance by either telomerase activity or the recombination-mediated alternative lengthening of telomeres (ALT) mechanism is a hallmark of cancer. Tumors that use ALT as their telomere maintenance mechanism are...
10.
Hibma M, Real N, Wiles A, Dobson-Le D, Dix B, Wynford-Thomas D, et al.
Virus Res
. 2009 Jul;
145(1):112-20.
PMID: 19576936
The Adenovirus (Ad) dl309 mutant, which lacks several E3 region genes, has been used as the backbone for a number of replication selective cytopathic Ads designed to treat tumours. We...