Anna M Costa
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Explore the profile of Anna M Costa including associated specialties, affiliations and a list of published articles.
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24
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148
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Recent Articles
1.
Crovara F, Marti J, Costa A, Vilarrasa J
J Org Chem
. 2024 Sep;
89(19):14483-14488.
PMID: 39287987
The direct insertion of Zn into olefin-halide bonds is a challenge. When ()-alkenyl iodides were treated with a very large excess of Zn nanoparticles, in the presence of Pd(PPh), the...
2.
Galeote O, Kennington S, Benedito G, Fraedrich L, Davies-Howe E, Costa A, et al.
Angew Chem Int Ed Engl
. 2024 Jan;
63(12):e202319308.
PMID: 38231568
Direct and stereodivergent Michael additions of N-acyl 1,3-thiazinane-2-thiones to α,β-unsaturated aldehydes catalyzed by chiral nickel(II) complexes are reported. The reactions proceed with a remarkable regio-, diastereo-, and enantioselectivity, so access...
3.
Costa A
Molecules
. 2023 Jul;
28(13).
PMID: 37446910
Amphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus . Although all of them display potent-to-moderate cytotoxicity, their...
4.
Mellado-Hidalgo M, Romero-Cavagnaro E, Nageswaran S, Puddu S, Kennington S, Costa A, et al.
Org Lett
. 2023 Jan;
25(4):659-664.
PMID: 36700336
A direct and asymmetric -aldol reaction of -acyl-1,3-oxazinane-2-thiones with dialkyl acetals from aromatic acetals in the presence of 2-5 mol % [DTBM-SEGPHOS]NiCl, TMSOTf, and lutidine has been developed. It has...
5.
Costa A, Cascales V, Castro-Alvarez A, Vilarrasa J
ACS Omega
. 2022 Jun;
7(22):18247-18258.
PMID: 35694469
The tendency of carbonyl compounds to form iminium ions by reaction with pyrrolidine or chiral pyrrolidine derivatives (in other words, the relative stability to hydrolysis of these iminium ions) has...
6.
Costa A, Bosch L, Petit E, Vilarrasa J
J Org Chem
. 2021 Apr;
86(10):7107-7118.
PMID: 33914532
A long series of Michael acceptors are studied computationally as potential alternatives to the maleimides that are used in most antibody-drug conjugates to link Cys of mAbs with cytotoxic drugs....
7.
Petit E, Bosch L, Costa A, Rodriguez-Izquierdo I, Sepulveda-Crespo D, Munoz-Fernandez M, et al.
ChemMedChem
. 2021 Apr;
16(14):2217-2222.
PMID: 33843142
Amides from indole-3-glyoxylic acid and 4-benzoyl-2-methylpiperazine, which are related to entry inhibitors developed by Bristol-Myers Squibb (BMS), have been synthesized with aliphatic chains located at the C7 position of the...
8.
Cascales V, Carneros H, Castro-Alvarez A, Costa A, Vilarrasa J
Org Lett
. 2021 Jan;
23(3):651-655.
PMID: 33428407
Chiral nitroalkenes are used for the first time in Michael additions of aldehydes, catalyzed by pyrrolidine derivatives. They yield the same major stereoisomer with either ()-proline or ()-proline, but this...
9.
Castro-Alvarez A, Carneros H, Calafat J, Costa A, Marco C, Vilarrasa J
ACS Omega
. 2019 Nov;
4(19):18167-18194.
PMID: 31720519
The addition of aldehyde enamines to nitroalkenes affords cyclobutanes in all solvents, with all of the pyrrolidine and proline derivatives tested by us and with all of the substrates we...
10.
Petit E, Bosch L, Costa A, Vilarrasa J
J Org Chem
. 2019 Aug;
84(17):11170-11176.
PMID: 31409066
We have developed a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thiol...