Anna Kakehashi
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Explore the profile of Anna Kakehashi including associated specialties, affiliations and a list of published articles.
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85
Citations
546
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Recent Articles
1.
Suzuki S, Gi M, Yanagiba Y, Yoneda N, Uehara S, Yokota Y, et al.
J Toxicol Pathol
. 2025 Jan;
38(1):59-67.
PMID: 39839725
Occupational exposure to aromatic amines is a major risk factor for urinary bladder cancer. Our previous studies showed that acetoaceto--toluidine, which is produced using -toluidine as a raw material, promotes...
2.
Urinary bladder carcinogenic potential of 4,4'-methylenebis(2-chloroaniline) in humanized-liver mice
Suzuki S, Gi M, Kobayashi T, Miyoshi N, Yoneda N, Uehara S, et al.
Toxicol Sci
. 2024 Sep;
202(2):210-219.
PMID: 39287002
Occupational exposure to 4,4'-methylenebis(2-chloroaniline) (MOCA) has been linked to an increased risk of bladder cancer among employees in Japanese plants, indicating its significance as a risk factor for urinary bladder...
3.
Sheema A, Naiki-Ito A, Kakehashi A, Ahmed O, Alexander D, Alexander W, et al.
Arch Toxicol
. 2024 Sep;
98(12):4143-4158.
PMID: 39269499
Fullerene whiskers (FLW)s are thin rod-like structures composed of C and C fullerene (FL). The shape of FLWs suggests potential toxic effects including carcinogenicity to the lung and pleura, similar...
4.
Vachiraarunwong A, Gi M, Kiyono T, Suzuki S, Fujioka M, Qiu G, et al.
Arch Toxicol
. 2024 Apr;
98(7):2065-2084.
PMID: 38630284
Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing...
5.
Tagami M, Kasashima H, Kakehashi A, Yoshikawa A, Nishio M, Misawa N, et al.
Front Oncol
. 2024 Feb;
14:1277749.
PMID: 38322414
Purpose: To examine the molecular biological differences between conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma and orbital MALT lymphoma in ocular adnexa lymphoma. Methods: Observational case series. A total of 129...
6.
Suzuki S, Gi M, Komiya M, Obikane A, Vachiraarunwong A, Fujioka M, et al.
Biomolecules
. 2024 Jan;
14(1).
PMID: 38254636
Occupational exposure to aromatic amines (AAs) is an important risk factor for urinary bladder cancer. This study aimed to evaluate the toxicity of AAs and analyze the carcinogenic mechanisms in...
7.
Yamamoto T, Gi M, Yamashita S, Suzuki S, Fujioka M, Vachiraarunwong A, et al.
Cancers (Basel)
. 2023 Nov;
15(21).
PMID: 37958445
Arsenic is a known human urinary bladder carcinogen. While arsenic is known to cause aberrant DNA methylation, the mechanism of arsenic-triggered bladder carcinogenesis is not fully understood. The goal of...
8.
Kakehashi A, Suzuki S, Wanibuchi H
Cancers (Basel)
. 2023 Sep;
15(18).
PMID: 37760534
Non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (NASH) are chronic hepatic conditions leading to hepatocellular carcinoma (HCC) development. According to the recent "multiple-parallel-hits...
9.
Suzuki S, Gi M, Fujioka M, Kakehashi A, Wanibuchi H
Toxicol Lett
. 2023 Aug;
384:128-135.
PMID: 37567419
Dimethylarsinic acid (DMA) is a major metabolite in the urine of humans and rats exposed to inorganic arsenicals, and is reported to induce rat bladder carcinogenesis. In the present study,...
10.
Yokota Y, Suzuki S, Gi M, Yanagiba Y, Yoneda N, Fujioka M, et al.
Toxicology
. 2023 Mar;
488:153483.
PMID: 36870411
Occupational exposure to aromatic amines is one of the most important risk factors for urinary bladder cancer. When considering the carcinogenesis of aromatic amines, metabolism of aromatic amines in the...