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Anna E Skrzypiec

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Articles 8
Citations 359
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Recent Articles
1.
Mucha M, Skrzypiec A, Kolenchery J, Brambilla V, Patel S, Labrador-Ramos A, et al.
Nat Commun . 2023 May; 14(1):2134. PMID: 37185241
Severe psychological trauma triggers genetic, biochemical and morphological changes in amygdala neurons, which underpin the development of stress-induced behavioural abnormalities, such as high levels of anxiety. miRNAs are small, non-coding...
2.
Zhang J, Bhuiyan M, Zhang T, Karimy J, Wu Z, Fiesler V, et al.
Nat Commun . 2020 Jan; 11(1):78. PMID: 31911626
The SLC12A cation-Cl cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx...
3.
Harlalka G, McEntagart M, Gupta N, Skrzypiec A, Mucha M, Chioza B, et al.
Hum Mutat . 2016 Aug; 37(11):1157-1161. PMID: 27492651
Hereditary spastic paraplegias (HSPs) are genetically and clinically heterogeneous axonopathies primarily affecting upper motor neurons and, in complex forms, additional neurons. Here, we report two families with distinct recessive mutations...
4.
Skrzypiec A, Shah R, Schiavon E, Baker E, Skene N, Pawlak R, et al.
PLoS One . 2013 Apr; 8(4):e61046. PMID: 23593384
Behavioural adaptation to psychological stress is dependent on neuronal plasticity and dysfunction at this cellular level may underlie the pathogenesis of affective disorders such as depression and post-traumatic stress disorder....
5.
Mucha M, Skrzypiec A, Schiavon E, Attwood B, Kucerova E, Pawlak R
Proc Natl Acad Sci U S A . 2011 Oct; 108(45):18436-41. PMID: 21969573
Psychological stress causes adaptive changes in the nervous system directed toward maintaining homoeostasis. These biochemical and structural mechanisms regulate animal behavior, and their malfunction may result in various forms of...
6.
Attwood B, Bourgognon J, Patel S, Mucha M, Schiavon E, Skrzypiec A, et al.
Nature . 2011 Apr; 473(7347):372-5. PMID: 21508957
A minority of individuals experiencing traumatic events develop anxiety disorders. The reason for the lack of correspondence between the prevalence of exposure to psychological trauma and the development of anxiety...
7.
Skrzypiec A, Maiya R, Chen Z, Pawlak R, Strickland S
Biol Psychiatry . 2009 Jul; 66(8):785-94. PMID: 19577227
Background: Alcoholism may result in severe neurological deficits and cognitive impairments. Many of the central effects of ethanol (EtOH) can be explained by upregulation of N-methyl-D-aspartate (NMDA) and downregulation of...
8.
Pawlak R, Melchor J, Matys T, Skrzypiec A, Strickland S
Proc Natl Acad Sci U S A . 2005 Jan; 102(2):443-8. PMID: 15630096
Chronic ethanol abuse causes up-regulation of NMDA receptors, which underlies seizures and brain damage upon ethanol withdrawal (EW). Here we show that tissue-plasminogen activator (tPA), a protease implicated in neuronal...