Ann L Hubbard
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Explore the profile of Ann L Hubbard including associated specialties, affiliations and a list of published articles.
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15
Citations
684
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Recent Articles
1.
Gupta A, Schell M, Bhattacharjee A, Lutsenko S, Hubbard A
J Cell Sci
. 2016 Jan;
129(6):1179-89.
PMID: 26823605
The cellular machinery responsible for Cu(+)-stimulated delivery of the Wilson-disease-associated protein ATP7B to the apical domain of hepatocytes is poorly understood. We demonstrate that myosin Vb regulates the Cu(+)-stimulated delivery...
2.
Braiterman L, Gupta A, Chaerkady R, Cole R, Hubbard A
J Biol Chem
. 2015 Feb;
290(14):8803-19.
PMID: 25666620
The Wilson disease protein ATP7B exhibits copper-dependent trafficking. In high copper, ATP7B exits the trans-Golgi network and moves to the apical domain of hepatocytes where it facilitates elimination of excess...
3.
Nyasae L, Schell M, Hubbard A
Traffic
. 2014 Sep;
15(12):1344-65.
PMID: 25243755
Physiologic Cu levels regulate the intracellular location of the Cu ATPase ATP7B. Here, we determined the routes of Cu-directed trafficking of endogenous ATP7B in the polarized hepatic cell line WIF-B...
4.
Braiterman L, Murthy A, Jayakanthan S, Nyasae L, Tzeng E, Gromadzka G, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(14):E1364-73.
PMID: 24706876
Wilson disease (WD) is a monogenic autosomal-recessive disorder of copper accumulation that leads to liver failure and/or neurological deficits. WD is caused by mutations in ATP7B, a transporter that loads...
5.
In J, Lukyanenko V, Foulke-Abel J, Hubbard A, Delannoy M, Hansen A, et al.
PLoS One
. 2013 Jul;
8(7):e69196.
PMID: 23874912
Life-threatening intestinal and systemic effects of the Shiga toxins produced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intestinal epithelial cells. We have recently demonstrated that EHEC...
6.
Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein
Gupta A, Bhattacharjee A, Dmitriev O, Nokhrin S, Braiterman L, Hubbard A, et al.
Proc Natl Acad Sci U S A
. 2011 Mar;
108(13):5390-5.
PMID: 21406592
In human disorders, the genotype-phenotype relationships are often complex and influenced by genetic and/or environmental factors. Wilson disease (WD) is a monogenic disorder caused by mutations in the copper-transporting P-type...
7.
Lutsenko S, Bhattacharjee A, Hubbard A
Metallomics
. 2010 Nov;
2(9):596-608.
PMID: 21072351
Copper plays an indispensable role in the physiology of the human central nervous system (CNS). As a cofactor of dopamine-β-hydroxylase, peptidyl-α-monooxygenase, superoxide dismutases, and many other enzymes, copper is a...
8.
Leitch S, Feng M, Muend S, Braiterman L, Hubbard A, Rao R
Biometals
. 2010 Oct;
24(1):159-70.
PMID: 20981470
Manganese is a trace element that is an essential co-factor in many enzymes critical to diverse biological pathways. However, excess Mn(2+) leads to neurotoxicity, with psychiatric and motor dysfunction resembling...
9.
Barnes N, Bartee M, Braiterman L, Gupta A, Ustiyan V, Zuzel V, et al.
Traffic
. 2009 May;
10(6):767-79.
PMID: 19416479
Human Cu-ATPases ATP7A and ATP7B maintain copper homeostasis through regulated trafficking between intracellular compartments. Inactivation of these transporters causes Menkes disease and Wilson disease, respectively. In Menkes disease, copper accumulates...
10.
Hubbard A, Braiterman L
Gastroenterology
. 2008 Apr;
134(4):1255-7.
PMID: 18395105
No abstract available.