Ann Greer
Overview
Explore the profile of Ann Greer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
473
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Zimmermann K, Wittman M, Saulnier M, Velaparthi U, Langley D, Sang X, et al.
Bioorg Med Chem Lett
. 2008 Jun;
18(14):4075-80.
PMID: 18572407
3-(Benzimidazol-2-yl)-pyridine-2-one-based ATP competitive inhibitors of Insulin-like Growth Factor 1 Kinase (IGF-IR) were optimized for reduced Cyp3A4 inhibition and improved oral exposure. The use of malonate as methyl anion synthon via...
12.
Saulnier M, Frennesson D, Wittman M, Zimmermann K, Velaparthi U, Langley D, et al.
Bioorg Med Chem Lett
. 2008 Feb;
18(5):1702-7.
PMID: 18258427
A series of IGF-1R inhibitors is disclosed, wherein the (m-chlorophenyl)ethanol side chain of BMS-536924 (1) is replaced with a series of 2-(1H-imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chains. Some analogs show improved...
13.
Velaparthi U, Liu P, Balasubramanian B, Carboni J, Attar R, Gottardis M, et al.
Bioorg Med Chem Lett
. 2007 Apr;
17(11):3072-6.
PMID: 17398093
A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450...
14.
Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, et al.
Bioorg Med Chem Lett
. 2007 Feb;
17(8):2317-21.
PMID: 17317169
The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme...
15.
Wittman M, Balasubramanian B, Stoffan K, Velaparthi U, Liu P, Krishnanathan S, et al.
Bioorg Med Chem Lett
. 2006 Dec;
17(4):974-7.
PMID: 17187980
A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
16.
Wittman M, Carboni J, Attar R, Balasubramanian B, Balimane P, Brassil P, et al.
J Med Chem
. 2005 Sep;
48(18):5639-43.
PMID: 16134929
Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivo biological...