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Ann D Nguyen

Explore the profile of Ann D Nguyen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 123
Followers 0
Related Specialties
Endocrinology
General Medicine
Biochemistry
Top 10 Co-Authors
Alan J Conley
C Jo Corbin
J Christina Pattison
Ian M Bird
Wendy Saltzman
Lisandra L Martin
Jie Zheng
David H Abbott
Michael W Parker
Alexandr N Simonov
Published In
Endocrinology
J Endocrinol
Mol Cell Endocrinol
J Biol Chem
Endocr Dev
Affiliations
Soon will be listed here.
Recent Articles
1.
Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)
Simonov A, Holien J, Yeung J, Nguyen A, Corbin C, Zheng J, et al.
PLoS One . 2015 Nov; 10(11):e0141252. PMID: 26587646
Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit...
2.
Organization of cytochrome P450 enzymes involved in sex steroid synthesis: PROTEIN-PROTEIN INTERACTIONS IN LIPID MEMBRANES
Praporski S, Ng S, Nguyen A, Corbin C, Mechler A, Zheng J, et al.
J Biol Chem . 2009 Oct; 284(48):33224-32. PMID: 19805543
Mounting evidence underscores the importance of protein-protein interactions in the functional regulation of drug-metabolizing P450s, but few studies have been conducted in membrane environments, and none have examined P450s catalyzing...
3.
The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques
Nguyen A, Corbin C, Pattison J, Bird I, Conley A
Endocrinology . 2008 Nov; 150(4):1748-56. PMID: 19036885
Adrenarche is thought to be experienced only by humans and some Old World primates despite observed regression of an adrenal fetal zone and establishment of a functional zona reticularis (ZR)...
4.
Morphological adrenarche in rhesus macaques: development of the zona reticularis is concurrent with fetal zone regression in the early neonatal period
Nguyen A, Mapes S, Corbin C, Conley A
J Endocrinol . 2008 Sep; 199(3):367-78. PMID: 18787057
Human adrenarche is associated with the establishment of a functional zona reticularis (ZR) and increasing secretion of dehydroepiandrosterone (DHEA) in sulfated form (DS). Like most non-human primates, rhesus macaques are...
5.
Adrenal androgens in humans and nonhuman primates: production, zonation and regulation
Nguyen A, Conley A
Endocr Dev . 2008 May; 13:33-54. PMID: 18493132
The synthesis and secretion of large quantities of the adrenal androgens, dehydroepiandrosterone (DHEA) and its sulfoconjugate DHEA sulfate (DS), is a phenomenon that appears limited to humans and some nonhuman...
6.
Gender and gonadal status differences in zona reticularis expression in marmoset monkey adrenals: Cytochrome b5 localization with respect to cytochrome P450 17,20-lyase activity
Pattison J, Saltzman W, Abbott D, Hogan B, Nguyen A, Husen B, et al.
Mol Cell Endocrinol . 2007 Jan; 265-266:93-101. PMID: 17222503
Neonatal marmosets express an adrenal fetal zone comparable to humans. While adult males fail to express a functional ZR, with barely detectable blood DHEA levels, females produce higher levels of...
7.
Male marmoset monkeys express an adrenal fetal zone at birth, but not a zona reticularis in adulthood
Pattison J, Abbott D, Saltzman W, Nguyen A, Henderson G, Jing H, et al.
Endocrinology . 2004 Oct; 146(1):365-74. PMID: 15459122
Neonatal human males produce high levels of dehydroepiandrosterone (DHEA) and its sulfo-conjugated form (DS) that decline within a few months of birth, due to regression of the adrenal fetal zone...