Ann C Parplys
Overview
Explore the profile of Ann C Parplys including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
118
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Recent Articles
1.
Kohl S, Subtil F, Climenti V, Anees H, Parplys A, Engenhart-Cabillic R, et al.
Transl Oncol
. 2025 Mar;
55:102359.
PMID: 40088750
Objectives: Human papilloma virus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) cells are highly radiosensitive resulting from an elevated number of DNA double-strand breaks (DSB) remaining after irradiation. Partially...
2.
Trego K, Groesser T, Davalos A, Parplys A, Zhao W, Nelson M, et al.
Mol Cell
. 2016 Feb;
61(4):535-546.
PMID: 26833090
XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevelopmental progeroid disorder Cockayne...
3.
Wurster S, Hennes F, Parplys A, Seelbach J, Mansour W, Zielinski A, et al.
Oncotarget
. 2016 Jan;
7(9):9732-41.
PMID: 26799421
There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role...
4.
Parplys A, Zhao W, Sharma N, Groesser T, Liang F, Maranon D, et al.
Nucleic Acids Res
. 2015 Sep;
43(20):9817-34.
PMID: 26323318
NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) is a 27 kD chromosomal, vertebrate-specific protein, for which limited functional data exist. Here, we demonstrate that NUCKS1 shares extensive sequence...
5.
Parplys A, Kratz K, Speed M, Leung S, Schild D, Wiese C
DNA Repair (Amst)
. 2014 Oct;
24:87-97.
PMID: 25288561
RAD51-associated protein 1 (RAD51AP1) is critical for homologous recombination (HR) by interacting with and stimulating the activities of the RAD51 and DMC1 recombinases. In human somatic cells, knockdown of RAD51AP1...