Ann-Christine Gradtke
Overview
Explore the profile of Ann-Christine Gradtke including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
60
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Recent Articles
1.
Mentrup T, Stumpff-Niggemann A, Leinung N, Schlosser C, Schubert K, Wehner R, et al.
Nat Commun
. 2022 Apr;
13(1):1880.
PMID: 35388002
Sensing of pathogens by pattern recognition receptors (PRR) is critical to initiate protective host defence reactions. However, activation of the immune system has to be carefully titrated to avoid tissue...
2.
Gradtke A, Mentrup T, Lehmann C, Cabrera-Cabrera F, Desel C, Okakpu D, et al.
J Immunol
. 2020 Nov;
206(1):164-180.
PMID: 33239420
Signal peptide peptidase-like 2a (SPPL2a) is an aspartyl intramembrane protease essential for degradation of the invariant chain CD74. In humans, absence of SPPL2a leads to Mendelian susceptibility to mycobacterial disease,...
3.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig A, Happ K, Gijbels M, et al.
J Exp Med
. 2019 Mar;
216(4):807-830.
PMID: 30819724
The lectin-like oxidized LDL receptor 1 (LOX-1) is a key player in the development of atherosclerosis. LOX-1 promotes endothelial activation and dysfunction by mediating uptake of oxidized LDL and inducing...
4.
Dudeck J, Medyukhina A, Frobel J, Svensson C, Kotrba J, Gerlach M, et al.
J Exp Med
. 2017 Nov;
214(12):3791-3811.
PMID: 29084819
Mast cells (MCs) and dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces. Using longitudinal intravital multiphoton microscopy of DC/MC reporter mice, we herein provide in vivo evidence that...