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Anke J Roelofs

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Articles 37
Citations 1345
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Recent Articles
1.
Roelofs A, McClure J, Hay E, De Bari C
Nat Rev Rheumatol . 2025 Mar; PMID: 40045009
Damage to articular cartilage, tendons, ligaments and entheses as a result of trauma, degeneration or inflammation in rheumatic diseases is prevalent. Regenerative medicine offers promising strategies for repairing damaged tissues,...
2.
Malamud M, Whitehead L, McIntosh A, Colella F, Roelofs A, Kusakabe T, et al.
Nature . 2024 Aug; 633(8029):442-450. PMID: 39143217
Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if...
3.
McClure J, Mcilroy G, Symons R, Clark S, Cunningham I, Han W, et al.
Osteoarthritis Cartilage . 2024 Aug; 32(12):1552-1565. PMID: 39103079
Objective: Obesity increases osteoarthritis (OA) risk due to adipose tissue dysfunction with associated metabolic syndrome and excess weight. Lipodystrophy syndromes exhibit systemic metabolic and inflammatory abnormalities similar to obesity without...
4.
Karabayas M, Ibrahim H, Roelofs A, Reynolds G, Kidder D, De Bari C
Ann Rheum Dis . 2024 Apr; 83(9):1100-1109. PMID: 38684323
Giant cell arteritis (GCA), the most common systemic vasculitis, is characterised by aberrant interactions between infiltrating and resident cells of the vessel wall. Ageing and breach of tolerance are prerequisites...
5.
Roelofs A, De Bari C
Osteoarthritis Cartilage . 2023 Nov; 32(2):148-158. PMID: 37944663
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy...
6.
Jaswal A, Kumar B, Roelofs A, Iqbal S, Singh A, Riemen A, et al.
Osteoarthritis Cartilage . 2023 Jul; 31(11):1454-1468. PMID: 37392862
Objective: To explore the significance of BMP signaling in osteoarthritis (OA) etiology, and thereafter propose a disease-modifying therapy for OA. Methods: To examine the role of the BMP signaling in...
7.
Tzvetkov J, Stephen L, Dillon S, Millan J, Roelofs A, De Bari C, et al.
J Bone Miner Res . 2023 Feb; 38(5):792-807. PMID: 36824055
Lipids play a crucial role in signaling and metabolism, regulating the development and maintenance of the skeleton. Membrane lipids have been hypothesized to act as intermediates upstream of orphan phosphatase...
8.
Collins F, Roelofs A, Symons R, Kania K, Campbell E, Collie-Duguid E, et al.
Ann Rheum Dis . 2022 Nov; 82(3):428-437. PMID: 36414376
Objectives: Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and + connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin and relationship with adult progenitors....
9.
Symons R, Colella F, Collins F, Rafipay A, Kania K, McClure J, et al.
Ann Rheum Dis . 2021 Nov; 81(2):214-224. PMID: 34844926
Objective: We aimed to understand the role of the transcriptional co-factor Yes-associated protein (Yap) in the molecular pathway underpinning the pathogenic transformation of synovial fibroblasts (SF) in rheumatoid arthritis (RA)...
10.
Perry J, Roelofs A, Mennan C, McCarthy H, Richmond A, Clark S, et al.
Cells . 2021 Aug; 10(8). PMID: 34440768
Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could...