Anja Ehrhardt
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Explore the profile of Anja Ehrhardt including associated specialties, affiliations and a list of published articles.
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119
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2982
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Recent Articles
1.
Dawson L, Alshawabkeh M, Schroer K, Arakrak F, Ehrhardt A, Zhang W
Eng Microbiol
. 2024 Dec;
4(1):100140.
PMID: 39628785
Adenoviruses typically cause mild illnesses, but severe diseases may occur primarily in immunodeficient individuals, particularly children. Recently, adenoviruses have garnered significant interest as a versatile tool in gene therapy, tumor...
2.
Wang X, Aurich K, Zhang W, Ehrhardt A, Greinacher A, Bayer W
Viruses
. 2024 Nov;
16(11).
PMID: 39599861
Adenoviruses are important human pathogens that are widespread and mainly associated with respiratory and gastrointestinal infections. In a previous study on human adenovirus (HAdV) seroprevalence, we observed reduced binding antibody...
3.
ADEVO: Proof-of-concept of adenovirus-directed EVOlution by random peptide display on the fiber knob
Sallard E, Fischer J, Schroeer K, Dawson L, Beaude N, Affes A, et al.
Mol Ther Oncol
. 2024 Sep;
32(4):200867.
PMID: 39346764
Directed evolution of viral vectors involves the generation of randomized libraries followed by artificial selection of improved variants. Directed evolution only yielded limited results in adenovirus (AdV) engineering until now,...
4.
Seuthe I, Krause L, Ruwe M, Silling S, Ehrhardt A, Eichhorn S, et al.
Pathol Res Pract
. 2024 Aug;
262:155541.
PMID: 39173463
Objectives: Investigating the expression and prognostic significance of adenovirus receptors DSG-2, CXADR and CD46 in head and neck cancer. Methods: 104 patients with HNSCC (77 OPSCC, 27 LSCC) were retrospectively...
5.
Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures
Schafer T, Knol L, Haas F, Hartley A, Pernickel S, Jady A, et al.
EBioMedicine
. 2024 Jun;
105:105219.
PMID: 38941955
Background: Pancreatic ductal adenocarcinoma (PDAC) is a tumour entity with unmet medical need. To assess the therapeutic potential of oncolytic virotherapy (OVT) against PDAC, different oncolytic viruses (OVs) are currently...
6.
Scarsella L, Ehrke-Schulz E, Paulussen M, Thal S, Ehrhardt A, Aydin M
Viruses
. 2024 Mar;
16(3).
PMID: 38543743
Adenoviruses (Ad) have the potential to induce severe infections in vulnerable patient groups. Therefore, understanding Ad biology and antiviral processes is important to comprehend the signaling cascades during an infection...
7.
Wang X, Hetzel M, Zhang W, Ehrhardt A, Bayer W
Front Immunol
. 2023 Nov;
14:1286622.
PMID: 37915567
For the development of new adenovirus (AdV)-based vectors, it is important to understand differences in immunogenicity. In a side-by-side analysis, we evaluated the effect of 40 AdV types covering human...
8.
Sallard E, Schulte L, van den Boom A, Klimovitskii A, Knierer J, Hagedorn C, et al.
J Gene Med
. 2023 Aug;
26(1):e3576.
PMID: 37580111
Background: Adenoviral vectors are among the most frequently used vectors for gene therapy and cancer treatment. Most vectors are derived from human adenovirus (Ad) serotype 5 despite limited applicability caused...
9.
Bahlmann N, Mautner L, Hoyos M, Sallard E, Berger C, Dangel A, et al.
Genes (Basel)
. 2023 Jul;
14(7).
PMID: 37510253
As the MHC-I-pathway is key to antigen presentation to cytotoxic T-cells and, therefore, recognition by the host adaptive immune system, we hypothesized that SARS-CoV-2 including its Variants of Concern (VOCs),...
10.
Dietz J, Jacobsen F, Zhuge H, Daya N, Bigot A, Zhang W, et al.
J Neuromuscul Dis
. 2023 Jun;
10(4):575-592.
PMID: 37270809
Background: Depending on the therapy approach and disease background, the heterogeneity of muscular tissues complicates the development of targeted gene therapy, where either expression in all muscle types or restriction...