Angus J Robertson
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Explore the profile of Angus J Robertson including associated specialties, affiliations and a list of published articles.
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12
Citations
114
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Recent Articles
1.
Robertson A, Ying J, Bax A
Magn Reson (Gott)
. 2023 Oct;
2(1):129-138.
PMID: 37904772
Resonance assignment and structural studies of larger proteins by nuclear magnetic resonance (NMR) can be challenging when exchange broadening, multiple stable conformations, and H back-exchange of the fully deuterated chain...
2.
Shen Y, Robertson A, Bax A
J Mol Biol
. 2023 Jun;
435(11):168067.
PMID: 37330294
Considerable debate has focused on whether sampling of molecular dynamics trajectories restrained by crystallographic data can be used to develop realistic ensemble models for proteins in their natural, solution state....
3.
Berg H, Wirtz Martin M, Altincekic N, Alshamleh I, Bains J, Blechar J, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(46):e202205858.
PMID: 36115062
SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals....
4.
Robertson A, Ying J, Bax A
Chembiochem
. 2022 Aug;
23(19):e202200471.
PMID: 35972230
The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, M (3CL /Nsp5), is a key antiviral drug target. NMR spectroscopy of this large system proved challenging and resonance assignments have remained incomplete....
5.
Robertson A, Cruz-Navarrete F, Wood H, Vekaria N, Hounslow A, Bisson C, et al.
ACS Catal
. 2022 Jun;
12(5):3149-3164.
PMID: 35692864
Understanding the factors that underpin the enormous catalytic proficiencies of enzymes is fundamental to catalysis and enzyme design. Enzymes are, in part, able to achieve high catalytic proficiencies by utilizing...
6.
Chiliveri S, Robertson A, Shen Y, Torchia D, Bax A
Chem Rev
. 2021 Nov;
122(10):9307-9330.
PMID: 34766756
The measurement and application of residual dipolar couplings (RDCs) in solution NMR studies of biological macromolecules has become well established over the past quarter of a century. Numerous methods for...
7.
Robertson A, Courtney J, Shen Y, Ying J, Bax A
J Am Chem Soc
. 2021 Nov;
143(46):19306-19310.
PMID: 34757725
The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, M (3CLpro/Nsp5), is a promising antiviral drug target. We evaluate the concordance of models generated by the newly introduced AlphaFold2 structure prediction program...
8.
Wood H, Cruz-Navarrete F, Baxter N, Trevitt C, Robertson A, Dix S, et al.
Nat Commun
. 2020 Nov;
11(1):5538.
PMID: 33139716
Enzyme regulation is vital for metabolic adaptability in living systems. Fine control of enzyme activity is often delivered through post-translational mechanisms, such as allostery or allokairy. β-phosphoglucomutase (βPGM) from Lactococcus...
9.
Gonzalez-Delgado L, Walters-Morgan H, Salamaga B, Robertson A, Hounslow A, Jagielska E, et al.
Nat Chem Biol
. 2019 Nov;
16(1):24-30.
PMID: 31686030
Lysostaphin is a bacteriolytic enzyme targeting peptidoglycan, the essential component of the bacterial cell envelope. It displays a very potent and specific activity toward staphylococci, including methicillin-resistant Staphylococcus aureus. Lysostaphin...
10.
Barnes C, Robertson A, Louis J, Anfinrud P, Bax A
J Am Chem Soc
. 2019 Aug;
141(35):13762-13766.
PMID: 31432672
Brain tissue of Alzheimer's disease patients invariably contains deposits of insoluble, fibrillar aggregates of peptide fragments of the amyloid precursor protein (APP), typically 40 or 42 residues in length and...