Andy Hesketh
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Explore the profile of Andy Hesketh including associated specialties, affiliations and a list of published articles.
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14
Citations
204
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Recent Articles
1.
Blount B, Lu X, Driessen M, Jovicevic D, Sanchez M, Ciurkot K, et al.
Cell Genom
. 2023 Nov;
3(11):100418.
PMID: 38020971
We describe construction of the synthetic yeast chromosome XI () and reveal the effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project (Sc2.0) chromosome was assembled...
2.
Hesketh A, Bucca G, Smith C, Hong H
Front Microbiol
. 2021 Mar;
12:641756.
PMID: 33717038
Dalbavancin, vancomycin and chlorobiphenyl-vancomycin share a high degree of structural similarity and the same primary mode of drug action. All inhibit bacterial cell wall biosynthesis through complexation with intermediates in...
3.
Hesketh A, Oliver S
Curr Genet
. 2019 Apr;
65(4):893-897.
PMID: 30937517
This mini-review considers the idea that guanylate nucleotide energy charge acts as an integrative signal for the regulation of gene expression in eukaryotic cells and discusses possible routes for that...
4.
Hesketh A, Vergnano M, Oliver S
mBio
. 2019 Jan;
10(1).
PMID: 30670615
Correlations between gene transcription and the abundance of high-energy purine nucleotides in have often been noted. However, there has been no systematic investigation of this phenomenon in the absence of...
5.
Hesketh A, Vergnano M, Wan C, Oliver S
mBio
. 2017 Jul;
8(4).
PMID: 28743817
We have engineered to inducibly synthesize the prokaryotic signaling nucleotides cyclic di-GMP (cdiGMP), cdiAMP, and ppGpp in order to characterize the range of effects these nucleotides exert on eukaryotic cell...
6.
Hong H, Hesketh A
Methods Mol Biol
. 2016 Jun;
1440:31-46.
PMID: 27311662
Transcriptomics, the genome-wide analysis of gene transcription, has become an important tool for characterizing and understanding the signal transduction networks operating in bacteria. Here we describe a protocol for quantifying...
7.
Hesketh A, Deery M, Hong H
J Proteome Res
. 2015 May;
14(7):2915-28.
PMID: 25965010
Understanding how bacteria survive periods of cell wall stress is of fundamental interest and can help generate ideas for improved antibacterial treatments. In this study we use tandem mass tagging...
8.
Hesketh A, Hill C, Mokhtar J, Novotna G, Tran N, Bibb M, et al.
BMC Genomics
. 2011 May;
12:226.
PMID: 21569315
Background: A decline in the discovery of new antibacterial drugs, coupled with a persistent rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing resource. The future...
9.
Ratnakumar S, Hesketh A, Gkargkas K, Wilson M, Rash B, Hayes A, et al.
Mol Biosyst
. 2010 Oct;
7(1):139-49.
PMID: 20963216
Saccharomyces cerevisiae can survive extreme desiccation, but the molecular mechanisms are poorly understood. To define genes involved in desiccation tolerance, two complementary genome-wide approaches, phenomics and transcriptomics, have been used,...
10.
Hesketh A, Kock H, Mootien S, Bibb M
Mol Microbiol
. 2009 Nov;
74(6):1427-44.
PMID: 19906184
The availability of zinc was shown to have a marked influence on the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2). Production of actinorhodin and undecylprodigiosin was abolished when a novel...