Andy Greenfield
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Explore the profile of Andy Greenfield including associated specialties, affiliations and a list of published articles.
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65
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1696
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Recent Articles
1.
Kay R, Reeves R, Siggers P, Greenaway S, Mallon A, Wells S, et al.
Development
. 2024 Dec;
151(23).
PMID: 39629665
The role of anti-WNT ZNRF3 is central to determining gonadal fate: XY mice lacking functional ZNRF3 exhibit a highly variable gonadal sex reversal phenotype in the fetal period, characterised by...
2.
Greenfield A
Mamm Genome
. 2024 Oct;
PMID: 39461919
There is a thriving, worldwide, biomedical research community working to understand the molecular bases of diseases of all types, continuously driving improved diagnostics and therapies. Developments in genetics and experimental...
3.
Tobias E, Lucas-Herald A, Sagar D, Montezano A, Rios F, Camargo L, et al.
Endocrine
. 2024 Feb;
84(2):345-349.
PMID: 38400880
Purpose: Disorders/differences of sex development (DSD) result from variants in many different human genes but, frequently, have no detectable molecular cause. Methods: Detailed clinical and genetic phenotyping was conducted on...
4.
Mayere C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, et al.
Sci Adv
. 2022 May;
8(21):eabm0972.
PMID: 35613264
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here,...
5.
Warr N, Siggers P, May J, Chalon N, Pope M, Wells S, et al.
Reproduction
. 2022 Mar;
163(6):333-340.
PMID: 35315790
Sex determination in mammals is controlled by the dominance of either pro-testis (SRY-SOX9-FGF9) or pro-ovary (RSPO1-WNT4-FOXL2) genetic pathways during early gonad development in XY and XX embryos, respectively. We have...
6.
Arslan Ates E, Eltan M, Sahin B, Gurpinar Tosun B, Seven Menevse T, Geckinli B, et al.
Eur J Endocrinol
. 2022 Mar;
186(5):K25-K31.
PMID: 35235537
Background: The human INHA gene encodes the inhibin subunit alpha protein, which is common to both inhibin A and B. The functional importance of inhibins in male sex development, sexual...
7.
Cicek D, Warr N, Yesil G, Eker H, Bas F, Poyrazoglu S, et al.
Eur J Endocrinol
. 2021 Oct;
186(1):65-72.
PMID: 34714774
Context: Homozygous and heterozygous variants in PPP2R3C are associated with syndromic 46,XY complete gonadal dysgenesis (Myo-Ectodermo-Gonadal Dysgenesis (MEGD) syndrome), and impaired spermatogenesis, respectively. This study expands the role of PPP2R3C...
8.
Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo B, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301885
Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis....
9.
Greenfield A
Prog Mol Biol Transl Sci
. 2021 Jun;
182:1-28.
PMID: 34175039
Genome editing, particularly the use of CRISPR-Cas9-based methodologies, is revolutionizing biology through its impacts on research and the translation of these into applications in biomedicine. Somatic genome editing aimed at...
10.
Lovell-Badge R, Anthony E, Barker R, Bubela T, Brivanlou A, Carpenter M, et al.
Stem Cell Reports
. 2021 May;
16(6):1398-1408.
PMID: 34048692
The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant...