Andrew W Weflen
Overview
Explore the profile of Andrew W Weflen including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
209
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Recent Articles
1.
Nelms B, Waldron L, Barrera L, Weflen A, Goettel J, Guo G, et al.
Genome Biol
. 2016 Oct;
17(1):201.
PMID: 27687735
We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific...
2.
Weflen A, Baier N, Tang Q, van den Hof M, Blumberg R, Lencer W, et al.
Mol Biol Cell
. 2013 Jun;
24(15):2398-405.
PMID: 23741050
The neonatal receptor for immunoglobulin G (IgG; FcRn) prevents IgG degradation by efficiently sorting IgG into recycling endosomes and away from lysosomes. When bound to IgG-opsonized antigen complexes, however, FcRn...
3.
Royan S, Jones R, Koutsouris A, Roxas J, Falzari K, Weflen A, et al.
Mol Microbiol
. 2010 Nov;
78(5):1232-45.
PMID: 21091507
Enteric bacterial pathogens have evolved sophisticated strategies to evade host immune defences. Some pathogens deliver anti-inflammatory effector molecules into the host cell cytoplasm via a type III secretion system (T3SS)....
4.
Weflen A, Alto N, Viswanathan V, Hecht G
Cell Microbiol
. 2010 Jan;
12(7):919-29.
PMID: 20088948
Enteropathogenic Escherichia coli (EPEC) infection requires the injection of effector proteins into intestinal epithelial cells (IECs) via type 3 secretion. Type 3-secreted effectors can interfere with IEC signalling pathways via...
5.
Weflen A, Alto N, Hecht G
Ann N Y Acad Sci
. 2009 Jun;
1165:169-74.
PMID: 19538303
Enteropathogenic E. coli (EPEC) are a leading cause of infantile diarrhea in developing countries, resulting in millions of deaths each year. EPEC secrete virulence factors, also called effectors, directly into...
6.
Alto N, Weflen A, Rardin M, Yarar D, Lazar C, Tonikian R, et al.
J Cell Biol
. 2007 Sep;
178(7):1265-78.
PMID: 17893247
Bacterial toxins and effector proteins hijack eukaryotic enzymes that are spatially localized and display rapid signaling kinetics. However, the molecular mechanisms by which virulence factors engage highly dynamic substrates in...