Andrew T Ludlow
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Explore the profile of Andrew T Ludlow including associated specialties, affiliations and a list of published articles.
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34
Citations
1002
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Recent Articles
1.
Kim J, Ahn A, Ying J, Ludlow A
Sci Rep
. 2025 Feb;
15(1):6787.
PMID: 40000722
All cancer cells must adopt a telomere maintenance mechanism to achieve replicative immortality. Most human cancer cells utilize the enzyme telomerase to maintain telomeres. Alternative splicing of TERT regulates the...
2.
Chang D, Li S, Court Pinto K, Nguyen T, Shah V, Morales E, et al.
bioRxiv
. 2025 Feb;
PMID: 39975037
Over four million people undergo radiation therapy annually in the United States. Among these, more than 90% experience varying degrees of radiation-induced skin injury. Despite the enormity of the problem,...
3.
Kim J, Ahn A, Ying J, Pollens-Voigt J, Ludlow A
Geroscience
. 2024 Sep;
PMID: 39222198
Telomere shortening occurs with aging in immune cells and may be related to immunosenescence. Exercise can upregulate telomerase activity and attenuate telomere shortening in immune cells, but it is unknown...
4.
Miranda E, Varshney P, Mazo C, Shadiow J, Ludlow A, Haus J
Redox Biol
. 2024 Aug;
75:103300.
PMID: 39142179
Glyoxalase I (GLO1) is the primary enzyme for detoxification of the reactive dicarbonyl methylglyoxal (MG). Loss of GLO1 promotes accumulation of MG resulting in a recapitulation of diabetic phenotypes. We...
5.
Godwin J, Michel J, Ludlow A, Fruge A, Mobley C, Nader G, et al.
Am J Physiol Regul Integr Comp Physiol
. 2024 Jul;
327(3):R338-R348.
PMID: 39005083
Ribosomal DNA (rDNA) copies exist across multiple chromosomes, and interindividual variation in copy number is speculated to influence the hypertrophic response to resistance training. Thus, we examined if rDNA copy...
6.
Miranda E, Mey J, Blackburn B, Chaves A, Fuller K, Perkins R, et al.
J Appl Physiol (1985)
. 2023 Sep;
135(4):849-862.
PMID: 37675469
Nearly 40% of Americans have obesity and are at increased risk for developing type 2 diabetes. Skeletal muscle is responsible for >80% of insulin-stimulated glucose uptake that is attenuated by...
7.
Kim J, Sayed M, Ahn A, Slusher A, Ying J, Ludlow A
PLoS One
. 2023 Aug;
18(8):e0289327.
PMID: 37531400
Part of the regulation of telomerase activity includes the alternative splicing (AS) of the catalytic subunit telomerase reverse transcriptase (TERT). Although a therapeutic window for telomerase/TERT inhibition exists between cancer...
8.
Kim J, Ahn A, Ying J, Hickman E, Ludlow A
Exerc Sport Sci Rev
. 2023 Jun;
51(4):150-160.
PMID: 37288975
Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By protecting the telomeres (chromosome ends) and the genome, telomerase promotes...
9.
Slusher A, Kim J, Ribick M, Pollens-Voigt J, Bankhead A, Palmbos P, et al.
Mol Cancer Res
. 2022 Jul;
20(10):1574-1588.
PMID: 35852380
Implications: Manipulation of a core spliceosome protein reduces telomerase/hTERT splicing in lung cancer cells and results in slowed cancer cell growth and cell death, revealing a potential therapeutic strategy.
10.
Slusher A, Kim J, Ribick M, Ludlow A
Med Sci Sports Exerc
. 2022 Feb;
54(6):931-943.
PMID: 35135999
Introduction: Aerobic exercise maintains telomere length through increased human telomerase reverse transcriptase (hTERT) expression and telomerase enzyme activity. The impact of acute exercise on hTERT alternative splicing (AS) is unknown....