Andrew T Krueger
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Explore the profile of Andrew T Krueger including associated specialties, affiliations and a list of published articles.
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12
Citations
239
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Recent Articles
1.
Kent T, Rusanov T, Hoang T, Velema W, Krueger A, Copeland W, et al.
Nucleic Acids Res
. 2016 Sep;
44(19):9381-9392.
PMID: 27591252
DNA polymerase θ (Polθ) is a unique A-family polymerase that is essential for alternative end-joining (alt-EJ) of double-strand breaks (DSBs) and performs translesion synthesis. Because Polθ is highly expressed in...
2.
Cambria E, Renggli K, Ahrens C, Cook C, Kroll C, Krueger A, et al.
Biomacromolecules
. 2015 Jun;
16(8):2316-26.
PMID: 26098148
Synthetic extracellular matrices are widely used in regenerative medicine and as tools in building in vitro physiological culture models. Synthetic hydrogels display advantageous physical properties, but are challenging to modify...
3.
Krueger A, Kroll C, Sanchez E, Griffith L, Imperiali B
Angew Chem Int Ed Engl
. 2014 Feb;
53(10):2662-6.
PMID: 24481645
Described is the development and application of a versatile semisynthetic strategy, based on a combination of sortase-mediated coupling and tetrazine ligation chemistry, which can be exploited for the efficient incorporation...
4.
Krueger A, Imperiali B
Chembiochem
. 2013 Apr;
14(7):788-99.
PMID: 23609944
Fluorescence spectroscopy is a powerful tool for probing complex biological processes. The ubiquity of peptide-protein and protein-protein interactions in these processes has made them important targets for fluorescence labeling, and...
5.
Krueger A, Peterson L, Chelliserry J, Kleinbaum D, Kool E
J Am Chem Soc
. 2011 Oct;
133(45):18447-51.
PMID: 21981660
An unnatural base-pair architecture with base pairs 2.4 Å larger than the natural DNA-based genetic system (xDNA) is evaluated for its ability to function like DNA, encoding amino acids in...
6.
Jarchow-Choy S, Krueger A, Liu H, Gao J, Kool E
Nucleic Acids Res
. 2010 Oct;
39(4):1586-94.
PMID: 20947563
Template independent polymerases, and terminal deoxynucleotidyl transferase (TdT) in particular, have been widely used in enzymatic labeling of DNA 3'-ends, yielding fluorescently-labeled polymers. The majority of fluorescent nucleotides used as...
7.
Lu H, Krueger A, Gao J, Liu H, Kool E
Org Biomol Chem
. 2010 Apr;
8(12):2704-10.
PMID: 20407680
The development of alternative architectures for genetic information-encoding systems offers the possibility of new biotechnological tools as well as basic insights into the function of the natural system. In order...
8.
Krueger A, Kool E
Chem Biol
. 2009 Mar;
16(3):242-8.
PMID: 19318205
Recognition of the nucleic acid bases within the DNA scaffold comprises the basis for transmission of genetic information, dictating protein and cell assembly, organismal development, and evolution. Driven in part...
9.
Krueger A, Lu H, Hojland T, Liu H, Gao J, Kool E
Nucleic Acids Symp Ser (Oxf)
. 2008 Sep;
(52):455-6.
PMID: 18776450
Here we study the viability of an unnatural genetic system with size-expanded geometry (xDNA). xDNA contains base pairs 2.4 A larger than those of natural DNA. The expanded geometry is...
10.
Krueger A, Kool E
J Am Chem Soc
. 2008 Mar;
130(12):3989-99.
PMID: 18311973
We recently described the synthesis and helix assembly properties of expanded DNA (xDNA), which contains base pairs 2.4 A larger than natural DNA pairs. This designed genetic set is under...