Andrew S Mclellan
Overview
Explore the profile of Andrew S Mclellan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
170
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0
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Recent Articles
1.
Tosti E, Almeida A, Tran T, Barbachan E Silva M, Broin P, Dubin R, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Jun;
14(3):693-717.
PMID: 35688320
Background And Aims: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation...
2.
Akler G, Birch A, Schreiber-Agus N, Cai X, Cai G, Shi L, et al.
Mol Genet Genomic Med
. 2019 Dec;
8(2):e1053.
PMID: 31880409
Background: Next-generation sequencing (NGS)-based panels have gained traction as a strategy for reproductive carrier screening. Their value for screening Ashkenazi Jewish (AJ) individuals, who have benefited greatly from population-wide targeted...
3.
Mahajan M, Mclellan A
Methods Mol Biol
. 2019 Oct;
2076:85-108.
PMID: 31586323
Next-generation sequencing (NGS) is transforming clinical research and diagnostics, vastly enhancing our ability to identify novel disease-causing genetic mutations and perform comprehensive diagnostic testing in the clinic. Whole-exome sequencing (WES)...
4.
Ning Z, Mclellan A, Ball M, Wynne F, ONeill C, Mills W, et al.
Hum Mol Genet
. 2015 Nov;
24(25):7450.
PMID: 26534778
No abstract available.
5.
Ning Z, Mclellan A, Ball M, Wynne F, ONeill C, Mills W, et al.
Hum Mol Genet
. 2015 Jun;
24(18):5126-41.
PMID: 26089202
Sprouty proteins are regulators of cell growth and branching morphogenesis. Unlike mouse Spry3, which is X-linked, human SPRY3 maps to the pseudoautosomal region 2; however, the human Y-linked allele is...
6.
Ramos M, Wijetunga N, Mclellan A, Suzuki M, Greally J
Epigenetics Chromatin
. 2015 Mar;
8:11.
PMID: 25806086
Background: DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological...
7.
Mclellan A, Dubin R, Jing Q, Broin P, Moskowitz D, Suzuki M, et al.
Genomics
. 2012 Sep;
100(6):345-51.
PMID: 22944616
The challenges associated with the management, analysis and interpretation of assays based on massively-parallel sequencing (MPS) are both individually complex and numerous. We describe what we believe to be the...
8.
Golden A, Mclellan A, Dubin R, Jing Q, Broin P, Moskowitz D, et al.
Stud Health Technol Inform
. 2012 Sep;
175:182-91.
PMID: 22942009
Massively-parallel sequencing (MPS) technologies and their diverse applications in genomics and epigenomics research have yielded enormous new insights into the physiology and pathophysiology of the human genome. The biggest hurdle...
9.
Mclellan A, Dubin R, Jing Q, Maqbool S, Olea R, Westby G, et al.
Epigenomics
. 2011 Nov;
1(1):33-8.
PMID: 22122636
There is increasing interest in the role of epigenetic and transcriptional dysregulation in the pathogenesis of a range of human diseases, not just in the best-studied example of cancer. It...
10.
Suzuki M, Oda M, Ramos M, Pascual M, Lau K, Stasiek E, et al.
Genome Res
. 2011 Sep;
21(11):1833-40.
PMID: 21957152
Heterochromatin is believed to be associated with increased levels of cytosine methylation. With the recent availability of genome-wide, high-resolution molecular data reflecting chromatin organization and methylation, such relationships can be...