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Andrew R Hamel

Explore the profile of Andrew R Hamel including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Advani J, Mehta P, Hamel A, Mehrotra S, Kiel C, Strunz T, et al.
Nat Commun . 2024 Mar; 15(1):1972. PMID: 38438351
DNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. We have analyzed array-based DNA methylation profiles of 160 human retinas with co-measured RNA-seq and >8 million...
2.
Hamel A, Yan W, Rouhana J, Monovarfeshani A, Jiang X, Mehta P, et al.
Nat Commun . 2024 Jan; 15(1):396. PMID: 38195602
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular...
3.
Han X, Gharahkhani P, Hamel A, Ong J, Renteria M, Mehta P, et al.
Nat Genet . 2023 Jun; 55(7):1116-1125. PMID: 37386247
Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma....
4.
Gharahkhani P, Jorgenson E, Hysi P, Khawaja A, Pendergrass S, Han X, et al.
Nat Commun . 2021 Feb; 12(1):1258. PMID: 33627673
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of...
5.
Barbeira A, Bonazzola R, Gamazon E, Liang Y, Park Y, Kim-Hellmuth S, et al.
Genome Biol . 2021 Jan; 22(1):49. PMID: 33499903
The resources generated by the GTEx consortium offer unprecedented opportunities to advance our understanding of the biology of human diseases. Here, we present an in-depth examination of the phenotypic consequences...
6.
Kim-Hellmuth S, Aguet F, Oliva M, Munoz-Aguirre M, Kasela S, Wucher V, et al.
Science . 2020 Sep; 369(6509). PMID: 32913075
The Genotype-Tissue Expression (GTEx) project has identified expression and splicing quantitative trait loci in cis (QTLs) for the majority of genes across a wide range of human tissues. However, the...
7.
Oliva M, Munoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz A, Cotter D, et al.
Science . 2020 Sep; 369(6509). PMID: 32913072
Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the...