Andrew Paul Hutchins
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Explore the profile of Andrew Paul Hutchins including associated specialties, affiliations and a list of published articles.
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26
Citations
578
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Recent Articles
1.
Ho S, Hu H, Ho D, Renom A, Yeung S, Boerner F, et al.
Stem Cell Reports
. 2025 Feb;
20(3):102398.
PMID: 39919754
SOX17 directs the differentiation toward endoderm and acts as a human germline specifier. We previously found that the replacement of glutamate at position 57 of the high-mobility group (HMG) box...
2.
Sun L, Fu X, Xiao Z, Ma G, Zhou Y, Hu H, et al.
Adv Sci (Weinh)
. 2024 Dec;
12(5):e2409160.
PMID: 39656858
Epigenetic control of cell fates is a critical determinant to maintain cell type stability and permit differentiation during embryonic development. However, the epigenetic control mechanisms are not well understood. Here,...
3.
Chen Y, Lu J, Xu Y, Huang Y, Wang D, Liang P, et al.
Protein Cell
. 2023 Mar;
14(7):477-496.
PMID: 36921016
Although somatic cells can be reprogrammed to pluripotent stem cells (PSCs) with pure chemicals, authentic pluripotency of chemically induced pluripotent stem cells (CiPSCs) has never been achieved through tetraploid complementation...
4.
Babarinde I, Hutchins A
BMC Genomics
. 2022 Jul;
23(1):487.
PMID: 35787153
Investigating the functions and activities of genes requires proper annotation of the transcribed units. However, transcript assembly efforts have produced a surprisingly large variation in the number of transcripts, and...
5.
Zou M, Duren Z, Yuan Q, Li H, Hutchins A, Wong W, et al.
Brief Bioinform
. 2021 Jun;
22(6).
PMID: 34180954
Multi-omics data allow us to select a small set of informative markers for the discrimination of specific cell types and study of cellular heterogeneity. However, it is often challenging to...
6.
Wang X, Veerapandian V, Yang X, Song K, Xu X, Cui M, et al.
Stem Cell Reports
. 2021 Apr;
16(5):1245-1261.
PMID: 33930315
In vitro induction of human primordial germ cell-like cells (hPGCLCs) provides an ideal platform to recapitulate hPGC development. However, the detailed molecular mechanisms regulating the induction of hPGCLCs remain largely...
7.
Fu X, He F, Li Y, Shahveranov A, Hutchins A
Cell Regen
. 2018 Jan;
6:1-7.
PMID: 29348912
Organisms are made of a limited number of cell types that combine to form higher order tissues and organs. Cell types have traditionally been defined by their morphologies or biological...
8.
Andrabi M, Hutchins A, Miranda-Saavedra D, Kono H, Nussinov R, Mizuguchi K, et al.
Sci Rep
. 2017 Jun;
7(1):4071.
PMID: 28642456
DNA shape is emerging as an important determinant of transcription factor binding beyond just the DNA sequence. The only tool for large scale DNA shape estimates, DNAshape was derived from...
9.
Huang K, Gao J, Du J, Ma N, Zhu Y, Wu P, et al.
Stem Cell Reports
. 2016 Oct;
7(5):854-868.
PMID: 27746115
The transition from hemogenic endothelial cells (HECs) to hematopoietic stem/progenitor cells (HS/PCs), or endothelial to hematopoietic transition (EHT), is a critical step during hematopoiesis. However, little is known about the...
10.
Pugacheva E, Teplyakov E, Wu Q, Li J, Chen C, Meng C, et al.
Epigenetics Chromatin
. 2016 Sep;
9(1):35.
PMID: 27588042
Background: A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription...