Andrew M K Brown
Overview
Explore the profile of Andrew M K Brown including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
1910
Followers
0
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Recent Articles
1.
Kim J, Zuzarte P, Murphy T, Chan-Seng-Yue M, Brown A, Krzyzanowski P, et al.
Leukemia
. 2019 Aug;
34(1):306-311.
PMID: 31435024
No abstract available.
2.
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson G, Connor A, et al.
Nature
. 2016 Nov;
542(7639):124.
PMID: 27851734
No abstract available.
3.
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson G, Connor A, et al.
Nature
. 2016 Oct;
538(7625):378-382.
PMID: 27732578
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor...
4.
Denroche R, Mullen L, Timms L, Beck T, Yung C, Stein L, et al.
BMC Res Notes
. 2015 Dec;
8:823.
PMID: 26708082
Background: Accurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task. Tumour samples are often contaminated with...
5.
Dube M, Zetler R, Barhdadi A, Brown A, Mongrain I, Normand V, et al.
Circ Cardiovasc Genet
. 2014 Sep;
7(6):880-6.
PMID: 25214527
Background: Statins (HMG-CoA reductase inhibitors) are the most prescribed class of lipid-lowering drugs for the treatment and prevention of cardiovascular disease. Creatine kinase (CK) is a commonly used biomarker to...
6.
Brown A, Renaud Y, Ross C, Hansen M, Mongrain I, Valois D, et al.
Pharmacogenomics
. 2014 Aug;
15(9):1185-95.
PMID: 25141894
Aim: To optimally address the interindividual variability observed in pharmacokinetic drug response, we have created a custom genotyping panel that interrogates most of the key genetic variations present in a...
7.
Miller J, Buchner N, Timms L, Tam S, Luo X, Brown A, et al.
PLoS One
. 2014 Feb;
9(2):e88163.
PMID: 24551080
Short tandem repeat (STR) analysis, such as the AmpFlSTR® Identifiler® Plus kit, is a standard, PCR-based human genotyping method used in the field of forensics. Misidentification of cell line and...
8.
Shlush L, Zandi S, Mitchell A, Chen W, Brandwein J, Gupta V, et al.
Nature
. 2014 Feb;
506(7488):328-33.
PMID: 24522528
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without...
9.
Watt S, Jiao W, Brown A, Petrocelli T, Tran B, Zhang T, et al.
Genomics
. 2013 Apr;
102(3):140-7.
PMID: 23603536
Using sequencing information to guide clinical decision-making requires coordination of a diverse set of people and activities. In clinical genomics, the process typically includes sample acquisition, template preparation, genome data...
10.
Kreso A, OBrien C, van Galen P, Gan O, Notta F, Brown A, et al.
Science
. 2012 Dec;
339(6119):543-8.
PMID: 23239622
Intratumoral heterogeneity arises through the evolution of genetically diverse subclones during tumor progression. However, it remains unknown whether cells within single genetic clones are functionally equivalent. By combining DNA copy...