Andrew Leach
Overview
Explore the profile of Andrew Leach including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
212
Followers
0
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Related Specialties
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Recent Articles
11.
Nowotka M, Gaulton A, Mendez D, Bento A, Hersey A, Leach A
Expert Opin Drug Discov
. 2017 Jun;
12(8):757-767.
PMID: 28602100
ChEMBL is a manually curated database of bioactivity data on small drug-like molecules, used by drug discovery scientists. Among many access methods, a REST API provides programmatic access, allowing the...
12.
McKinnon M, Howes J, Leach A, Prokop N
Public Underst Sci
. 2017 Mar;
27(5):562-577.
PMID: 28351213
Scientists, science communicators and science journalists interact to deliver science news to the public. Yet the value of interactions between the groups in delivering high-quality science stories is poorly understood...
13.
14.
Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies B, et al.
J Med Chem
. 2013 Feb;
56(5):2059-73.
PMID: 23394218
Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against...
15.
OBrien M, Leach A, Armstrong R, Chong K, Sheridan R
Org Biomol Chem
. 2012 Feb;
10(12):2392-4.
PMID: 22349413
Utilising the propensity of the 2-furanyl group to facilitate equilibration of an adjacent tosylamide chiral centre, a diastereoselective route to 2,6-syn-piperidines was developed that proceeds with high levels of thermodynamic...
16.
Brocklehurst K, Broo A, Butlin R, Brown H, Clarke D, Davidsson O, et al.
Bioorg Med Chem Lett
. 2011 Nov;
21(24):7310-6.
PMID: 22061639
GPR119 is increasingly seen as an attractive target for the treatment of type II diabetes and other elements of the metabolic syndrome. During a programme aimed at developing agonists of...
17.
Potyrailo R, Leach A, Morris W, Gamage S
Anal Chem
. 2006 Aug;
78(16):5633-8.
PMID: 16906705
We demonstrate an approach for the development of chemical sensors utilizing silicon micromachined physical transducers with integrated piezoresistive readout. Originally, these transducers were developed and optimized as sensitive accelerometers for...
18.
Bartlett S, Beddard G, Jackson R, Kayser V, Kilner C, Leach A, et al.
J Am Chem Soc
. 2005 Aug;
127(33):11699-708.
PMID: 16104747
The conformation of a bisindolylmaleimide may be controlled by the size of a macrocyclic ring in which it is constrained. A range of techniques were used to demonstrate that the...
19.
Hieftje G, Huang M, Lehn S, Warner K, Gamez G, Ray S, et al.
Anal Sci
. 2002 Dec;
18(11):1185-9.
PMID: 12458700
Although inductively coupled plasma emission and mass spectrometry have been in widespread use for a long time, there is still a gap in our knowledge concerning how atoms are formed...