Andrew Kneynsberg
Overview
Explore the profile of Andrew Kneynsberg including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
245
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0
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Recent Articles
1.
Padmanabhan P, Kneynsberg A, Cruz E, Briner A, Gotz J
Mol Brain
. 2024 Feb;
17(1):7.
PMID: 38347594
Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau's aggregation and loss- and gain-of-functions, including the interaction...
2.
Taylor D, Kneynsberg A, van Roijen M, Gotz J
Mol Brain
. 2023 Jan;
16(1):6.
PMID: 36639708
Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary tauopathies....
3.
Padmanabhan P, Kneynsberg A, Cruz E, Amor R, Sibarita J, Gotz J
EMBO J
. 2022 Aug;
41(19):e111265.
PMID: 36004506
Accumulation of aggregates of the microtubule-binding protein Tau is a pathological hallmark of Alzheimer's disease. While Tau is thought to primarily associate with microtubules, it also interacts with and localizes...
4.
Padmanabhan P, Kneynsberg A, Gotz J
Nat Rev Neurosci
. 2021 Nov;
22(12):723-740.
PMID: 34725519
The synapse has emerged as a critical neuronal structure in the degenerative process of Alzheimer disease (AD), in which the pathogenic signals of two key players - amyloid-β (Aβ) and...
5.
Combs B, Christensen K, Richards C, Kneynsberg A, Mueller R, Morris S, et al.
J Neurosci
. 2021 Oct;
41(45):9431-9451.
PMID: 34607969
Pathologic tau modifications are characteristic of Alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. Inherited mutations in tau cause early onset frontotemporal lobar dementias...
6.
Evans H, Taylor D, Kneynsberg A, Bodea L, Gotz J
Acta Neuropathol Commun
. 2021 Jun;
9(1):110.
PMID: 34147135
The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis...
7.
Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan N
Front Neurosci
. 2017 Nov;
11:572.
PMID: 29089864
Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well-established...
8.
Kneynsberg A, Kanaan N
eNeuro
. 2017 Aug;
4(4).
PMID: 28785724
Little is known about the specific contributions of aging to the neuron dysfunction and death in Alzheimer's disease (AD). AD is characterized by the pathological accumulation of abnormal tau (a...
9.
Kneynsberg A, Collier T, Manfredsson F, Kanaan N
J Neurosci Methods
. 2016 Apr;
266:32-41.
PMID: 27031947
Background: Axon viability is critical for maintaining neural connectivity, which is central to neural functionality. Many neurodegenerative diseases (e.g., Parkinson's disease (PD) and Alzheimer's disease) appear to involve extensive axonal...
10.
Combs B, Kneynsberg A, Kanaan N
Methods Mol Biol
. 2015 Nov;
1382:339-66.
PMID: 26611599
Dementias are among the most common neurological disorders, and Alzheimer's disease (AD) is the most common cause of dementia worldwide. AD remains a looming health crisis despite great efforts to...