Andrew Keniry
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Explore the profile of Andrew Keniry including associated specialties, affiliations and a list of published articles.
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31
Citations
2632
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Recent Articles
1.
Keenan C, Coughlan H, Iannarella N, Tapia Del Fierro A, Keniry A, Johanson T, et al.
Genome Res
. 2024 May;
34(4):556-571.
PMID: 38719473
H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes in differentiation and development. Here, we investigate the molecular...
2.
Short K, Tortelote G, Jones L, Diniz F, Edgington-Giordano F, Cullen-McEwen L, et al.
bioRxiv
. 2023 Dec;
PMID: 38106143
Background: Low nephron number has a direct impact on the development of hypertension and chronic kidney disease later in life. While intrauterine growth restriction caused by maternal low protein diet...
3.
Keniry A, Blewitt M
Development
. 2023 Nov;
150(22).
PMID: 37991053
In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin...
4.
Tapia Del Fierro A, den Hamer B, Benetti N, Jansz N, Chen K, Beck T, et al.
Nat Commun
. 2023 Sep;
14(1):5466.
PMID: 37749075
The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity...
5.
Keniry A, Jansz N, Hickey P, Breslin K, Iminitoff M, Beck T, et al.
Development
. 2022 Nov;
149(22).
PMID: 36355065
Female mouse embryonic stem cells (mESCs) present differently from male mESCs in several fundamental ways; however, complications with their in vitro culture have resulted in an under-representation of female mESCs...
6.
Benetti N, Gouil Q, Tapia Del Fierro A, Beck T, Breslin K, Keniry A, et al.
Nat Commun
. 2022 Jul;
13(1):4295.
PMID: 35879318
Parents transmit genetic and epigenetic information to their offspring. Maternal effect genes regulate the offspring epigenome to ensure normal development. Here we report that the epigenetic regulator SMCHD1 has a...
7.
Wanigasuriya I, Kinkel S, Beck T, Roper E, Breslin K, Lee H, et al.
Epigenetics Chromatin
. 2022 Jul;
15(1):26.
PMID: 35843975
Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one...
8.
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
Keniry A, Jansz N, Gearing L, Wanigasuriya I, Chen J, Nefzger C, et al.
Nat Commun
. 2022 Mar;
13(1):1658.
PMID: 35351876
The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishable female mouse embryonic stem cell (mESC) system, Xmas, that allows rapid assessment...
9.
Wanigasuriya I, Gouil Q, Kinkel S, Tapia Del Fierro A, Beck T, Roper E, et al.
Elife
. 2020 Nov;
9.
PMID: 33186096
Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in...
10.
Lau K, Mason E, Kie J, de Souza D, Kloehn J, Tull D, et al.
Nat Commun
. 2020 May;
11(1):2420.
PMID: 32415101
Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast stem cells, which correspond to pluripotent cells at a late post-implantation stage...