Andrew K Dingwall
Overview
Explore the profile of Andrew K Dingwall including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
413
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Recent Articles
1.
Zraly C, Schultz R, Diaz M, Dingwall A
Nucleic Acids Res
. 2023 Aug;
51(18):9672-9689.
PMID: 37638761
Enhancer activation by the MLR family of H3K4 mono-methyltransferases requires proper recognition of histones for the deposition of the mono-methyl mark. MLR proteins contain two clusters of PHD zinc finger...
2.
Ford D, Zraly C, Perez J, Dingwall A
Dev Biol
. 2020 Sep;
468(1-2):41-53.
PMID: 32946789
The conserved MLR COMPASS-like complexes are histone modifiers that are recruited by a variety of transcription factors to enhancer regions where they act as necessary epigenetic tools for enhancer establishment...
3.
Zraly C, Zakkar A, Perez J, Ng J, White K, Slattery M, et al.
Nucleic Acids Res
. 2020 Feb;
48(7):3476-3495.
PMID: 32052053
The MLR COMPASS complex monomethylates H3K4 that serves to epigenetically mark transcriptional enhancers to drive proper gene expression during animal development. Chromatin enrichment analyses of the Drosophila MLR complex reveals...
4.
Peiffer D, Wyatt D, Zlobin A, Piracha A, Ng J, Dingwall A, et al.
Cancer Res
. 2019 Aug;
79(19):4965-4977.
PMID: 31387918
Estrogen receptor (ER)-positive breast cancer recurrence is thought to be driven by tumor-initiating cells (TIC). TICs are enriched by endocrine therapy through NOTCH signaling. Side effects have limited clinical trial...
5.
Fagan R, Dingwall A
Cancer Lett
. 2019 May;
458:56-65.
PMID: 31128216
The KMT2 (lysine methyltransferase) family of histone modifying proteins play essential roles in regulating developmental pathways, and mutations in the genes encoding these proteins have been strongly linked to many...
6.
7.
Ford D, Dingwall A
Cancer Genet
. 2015 Mar;
208(5):178-91.
PMID: 25794446
The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2A-D) were previously linked to cancer through the founding member, MLL1/KMT2A, which is often involved in translocation-associated gene fusion events in...
8.
Chauhan C, Zraly C, Dingwall A
Dev Biol
. 2013 May;
380(2):185-98.
PMID: 23707261
Drosophila Cara Mitad (Cmi, also known as Lpt) is the N-terminal homolog of mammalian Mixed Lineage Leukemia 2 (MLL2/ALR), a core component of COMPASS-like nuclear receptor coactivator complexes. Cmi is...
9.
Curtis B, Zraly C, Dingwall A
Genesis
. 2012 Sep;
51(1):16-31.
PMID: 22965777
The choice and timing of specific developmental pathways in organogenesis are determined by tissue-specific temporal and spatial cues that are acted upon to impart unique cellular and compartmental identities. A...
10.
Chauhan C, Zraly C, Parilla M, Diaz M, Dingwall A
Development
. 2012 May;
139(11):1997-2008.
PMID: 22569554
MLL2 and MLL3 histone lysine methyltransferases are conserved components of COMPASS-like co-activator complexes. In vertebrates, the paralogous MLL2 and MLL3 contain multiple domains required for epigenetic reading and writing of...