Andrew J Simmonds
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Explore the profile of Andrew J Simmonds including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
336
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Recent Articles
1.
Cheng A, Simmonds A
Genome
. 2024 Oct;
68():1-12.
PMID: 39471439
Many cellular functions are compartmentalized within the optimized environments of organelles. However, processing or storage of metabolites from the same pathway can occur in multiple organelles. Thus, spatially separated organelles...
2.
Keegan S, Haskins J, Simmonds A, Hughes S
Development
. 2023 Jun;
150(13).
PMID: 37294080
Coordinated spatio-temporal regulation of the determination and differentiation of neural stem cells is essential for brain development. Failure to integrate multiple factors leads to defective brain structures or tumour formation....
3.
Ueda K, Anderson-Baron M, Haskins J, Hughes S, Simmonds A
J Cell Sci
. 2022 Mar;
135(7).
PMID: 35274690
Both peroxisomes and lipid droplets regulate cellular lipid homeostasis. Direct inter-organellar contacts as well as novel roles for proteins associated with peroxisome or lipid droplets occur when cells are induced...
4.
Nath A, Parsons B, Makdissi S, Chilvers R, Mu Y, Weaver C, et al.
Cell Rep
. 2022 Mar;
38(9):110433.
PMID: 35235794
Phagocytosis, signal transduction, and inflammatory responses require changes in lipid metabolism. Peroxisomes have key roles in fatty acid homeostasis and in regulating immune function. We find that Drosophila macrophages lacking...
5.
Liu Y, Weaver C, Sen Y, Eitzen G, Simmonds A, Linchieh L, et al.
Front Cell Dev Biol
. 2021 Aug;
9:714710.
PMID: 34434934
Peroxisome biogenesis disorders (PBDs) are a group of metabolic developmental diseases caused by mutations in one or more genes encoding peroxisomal proteins. Zellweger syndrome spectrum (PBD-ZSS) results from metabolic dysfunction...
6.
Merritt T, Simmonds A, Fernandez-Gonzalez R, Moehring A
Genome
. 2021 Feb;
64(2):vii-viii.
PMID: 33522424
No abstract available.
7.
Pridie C, Ueda K, Simmonds A
Front Cell Dev Biol
. 2020 Sep;
8:835.
PMID: 32984330
Research using the fruit fly has traditionally focused on understanding how mutations affecting gene regulation or function affect processes linked to animal development. Accordingly, flies have become an essential foundation...
8.
Huang K, Miao T, Chang K, Kim J, Kang P, Jiang Q, et al.
Nat Commun
. 2020 Jun;
11(1):2943.
PMID: 32523050
Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to...
9.
Pridie C, Simmonds A
Genome
. 2020 Mar;
64(2):119-137.
PMID: 32191843
Peroxisomes are organelles in eukaryotic cells responsible for processing several types of lipids and management of reactive oxygen species. A conserved family of peroxisome biogenesis (, ) genes encode proteins...
10.
Hughes S, Simmonds A
Front Genet
. 2019 Mar;
10:135.
PMID: 30899273
Multiple mechanisms tightly regulate mRNAs during their transcription, translation, and degradation. Of these, the physical localization of mRNAs to specific cytoplasmic regions is relatively easy to detect; however, linking localization...